Release of N-Terminal Pro-Brain Natriuretic Peptide in Children With Acute Rheumatic Carditis

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dc.contributor.authorÇimen, Ömer
dc.contributor.authorOran, Bülent
dc.contributor.authorÇimen, Derya
dc.contributor.authorBaysal, Tamer
dc.contributor.authorKaraaslan, Sevim
dc.contributor.authorÜnal, Ekrem
dc.contributor.authorBaşarılı, Kemal
dc.contributor.authorBüyükbaş, Sadık
dc.date.accessioned2020-03-26T18:04:54Z
dc.date.available2020-03-26T18:04:54Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Acute rheumatic carditis is still an important cause of cardiac failure in developing countries. B-type natriuretic peptides, especially N-terminal segment of its prohormone are now recognised as essential parrs of cardiologic evaluation. Increased plasma concentrations of B-type natriuretic peptide and its prohormone are markers of cardiac failure and hypoxia in adults. Aim: To measure the prohormone levels in children with acute rheumatic carchtis and to determine whether its concentrations correlate with clinical and laboratory findings. Methods: A total of 24 children with acute rheumatic carchtis and 23 age and sex-matched healthy subjects were entered in the study. Transthoracic echocardiography was performed in all patients to assess the severity of the valve insufficiency and cardiac dysfunction. The prohormone plasma levels were tested for correlation with cardiac dysfunction and other biochemical markers, such as C-reactive protein, erythrocyte sedimentation rate, and anti-streptolysin-O titter. Results: The prohormone plasma concentrations were significantly higher in children with acute rheumatic carditis than in control subjects at the rime of diagnosis. A significant decrease of the plasma level was detected among patients after treatments (6-8 weeks). Conclusion: We found increased plasma prohormone levels in children with acute rheumatic carditis in the acute stage of illness compared with healthy subjects. Another result is increased plasma prohormone levels as acute rheumatic carditis are reversible.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk Universityen_US
dc.description.sponsorshipThis study has been supported by a research grant of "Selcuk University Research Found". The authors thank Professor Said Bodur, MD, for assistance in the statistical analysis.en_US
dc.identifier.citationÇimen, Ö., Oran, B., Çimen, D., Baysal, T., Karaaslan, S., Ünal, E., Başarılı, K., Büyükbaş, S., (2010). Release of N-Terminal Pro-Brain Natriuretic Peptide in Children With Acute Rheumatic Carditis. Cardiology in the Young, (20), 297-301. Doi: 10.1017/S1047951110000089
dc.identifier.doi10.1017/S1047951110000089en_US
dc.identifier.endpage301en_US
dc.identifier.issn1047-9511en_US
dc.identifier.issn1467-1107en_US
dc.identifier.pmid20416140en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage297en_US
dc.identifier.urihttps://dx.doi.org/10.1017/S1047951110000089
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25216
dc.identifier.volume20en_US
dc.identifier.wosWOS:000278719100009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇimen, Ömer
dc.institutionauthorOran, Bülent
dc.institutionauthorÇimen, Derya
dc.institutionauthorBaysal, Tamer
dc.institutionauthorKaraaslan, Sevim
dc.institutionauthorÜnal, Ekrem
dc.institutionauthorBaşarılı, Kemal
dc.institutionauthorBüyükbaş, Sadık
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofCardiology in the Youngen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectN-terminal pro-B-type natriuretic peptideen_US
dc.subjectacute rheumatic carditisen_US
dc.subjectchildhooden_US
dc.titleRelease of N-Terminal Pro-Brain Natriuretic Peptide in Children With Acute Rheumatic Carditisen_US
dc.typeArticleen_US

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