Comparison of Treatment Responses and Clinical Characteristics of Early-Onset and Late-Onset Obsessive-Compulsive Disorder

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dc.contributor.authorUğuz, Faruk
dc.contributor.authorAşkın, Rüstem
dc.contributor.authorÇilli, Ali S.
dc.contributor.authorBeşiroğlu, Lütfullah
dc.date.accessioned2020-03-26T17:03:14Z
dc.date.available2020-03-26T17:03:14Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective. The clinical characteristics and response to pharmacotherapy of adult patients with early-onset and late-onset obsessive-compulsive disorder (OCD) were compared in this study. Methods. A total of 50 outpatients with OCD diagnosed according to DSM-IV criteria (early-onset: 20; late-onset: 30) were included in the study. After initial clinical evaluation with The Structured Clinical Interview for DSM-IV/Clinical Version (SCID-I/CV), The Structured Clinical Interview for DSM-III-R Personality Disorders (SCID-II) and Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), all patients were treated with fluvoxamine, sertraline or paroxetine for 12 weeks. Treatment response was defined as a >= 35% reduction in the Y-BOCS-total scores from baseline in a 12-week follow-up period. Results. Forty-three patients (early-onset: 16; late-onset: 27) completed the study. The early-onset group had higher frequencies of symmetry/exactness obsessions and ordering/arranging compulsions, and the late-onset group had higher mean age at assessment. Nine (56.3%) patients with early-onset and 18 (66.7%) with late-onset responded to pharmacotherapy. The difference between response rates was not statistically significant. Conclusions. Our study suggests that although there are some phenomenological differences between patients with early-onset OCD and late-onset OCD, these patients have similar responses to pharmacotherapy.en_US
dc.identifier.citationUğuz, F., Aşkın, R., Çilli, A. S., Beşiroğlu, L., (2006). Comparison of Treatment Responses and Clinical Characteristics of Early-Onset and Late-Onset Obsessive-Compulsive Disorder. International Journal of Psychiatry in Clinical Practice, 10(4), 291-296. Doi: 10.1080/13651500600811271
dc.identifier.doi10.1080/13651500600811271en_US
dc.identifier.endpage296en_US
dc.identifier.issn1365-1501en_US
dc.identifier.issue4en_US
dc.identifier.pmid24941149en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage291en_US
dc.identifier.urihttps://dx.doi.org/10.1080/13651500600811271
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20394
dc.identifier.volume10en_US
dc.identifier.wosWOS:000241819600011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUğuz, Faruk
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofInternational Journal of Psychiatry in Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectobsessive-compulsive disorderen_US
dc.subjectpharmacotherapyen_US
dc.subjectresponseen_US
dc.subjectearly-onseten_US
dc.subjectlate-onseten_US
dc.titleComparison of Treatment Responses and Clinical Characteristics of Early-Onset and Late-Onset Obsessive-Compulsive Disorderen_US
dc.typeArticleen_US

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