Evaluation of bone mineral density (BMD) and indicators of bone turnover in patients with hemophilia

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dc.contributor.authorDağlı, Mehmet
dc.contributor.authorKutlucan, Ali
dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorBaştürk, Abdulkadir
dc.contributor.authorSözen, Mehmet
dc.contributor.authorKutlucan, Leyla
dc.contributor.authorÜnlü, Ali
dc.contributor.authorYılmaz, Farise
dc.date.accessioned2020-03-26T19:53:48Z
dc.date.available2020-03-26T19:53:48Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü.en_US
dc.description.abstractA decrease in bone mass is observed in hemophilic patients. The aim of this study was to evaluate bone mineral density (BMD), parathyroid hormone (PTH), 25-hydroxy vitamin D (vitamin D), and a bone formation and resorption marker, procollagen type I N-terminal propeptide (PINP) and urinary N-terminal telopeptide (uNTX) respectively, in hemophilic patients and healthy controls. Laboratory parameters related to the pathogenesis of bone loss such as neutrophil- lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were also evaluated. Thirty-five men over 18 years of age, with severe hemophilia (A and B) and receiving secondary prophylaxis, were included in the study. The same number of age-, sex-, and ethnicity-matched healthy controls were evaluated. Anthropometric, biochemical, and hormonal parameters were determined in both groups. No significant difference in anthropometric parameters was found between the two groups. The BMD was low in 34% of hemophilic patients. Vitamin D, calcium, and free testosterone levels were significantly lower (p < 0.001, p = 0.011, p < 0.001, respectively), while PTH, PINP, and activated partial thromboplastin time (aPTT) levels were significantly higher (p < 0.014, p = 0.043, p < 0.001, respectively), in hemophilic patients compared to controls. There was no significant difference between the two groups in NLR, PLR, phosphorus, thyroid-stimulating hormone, and uNTX level. The reduction of bone mass in hemophilic patients may be evaluated using the markers of bone formation and resorption, enabling early detection and timely treatment.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk University [15401129]en_US
dc.description.sponsorshipThis work was supported by Selcuk University Scientific Research Project (Project No: 15401129).en_US
dc.identifier.citationDagli, M., Kutlucan, A., Abusoglu, S., Basturk, A., Sozen, M., Kutlucan, L., Unlu, A., Yilmaz, F. (2018). Evaluation of Bone Mineral Density (BMD) and Indicators of Bone Turnover in Patients with Hemophilia. Bosnian Journal of Basic Medical Sciences, 18(2), 206-210.
dc.identifier.doi10.17305/bjbms.2018.2335en_US
dc.identifier.endpage210en_US
dc.identifier.issn1512-8601en_US
dc.identifier.issn1840-4812en_US
dc.identifier.issue2en_US
dc.identifier.pmid29236646en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage206en_US
dc.identifier.urihttps://dx.doi.org/10.17305/bjbms.2018.2335
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36594
dc.identifier.volume18en_US
dc.identifier.wosWOS:000433285000013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDağlı, Mehmet
dc.institutionauthorKutlucan, Ali
dc.institutionauthorAbuşoğlu, Sedat
dc.institutionauthorBaştürk, Abdulkadir
dc.institutionauthorSözen, Mehmet
dc.institutionauthorÜnlü, Ali
dc.institutionauthorYılmaz, Farise
dc.language.isoenen_US
dc.publisherASSOC BASIC MEDICAL SCI FEDERATION BOSNIA & HERZEGOVINA SARAJEVOen_US
dc.relation.ispartofBOSNIAN JOURNAL OF BASIC MEDICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHemophiliaen_US
dc.subjectosteoporosisen_US
dc.subjectbone mineral densityen_US
dc.subjectBMDen_US
dc.subjectprocollagen type I N-terminal propeptideen_US
dc.subjectPINPen_US
dc.subjecturinary N-terminal telopeptideen_US
dc.subjectuNTXen_US
dc.subjectcomplete blood counten_US
dc.subjectCBCen_US
dc.subjectbone resorptionen_US
dc.subjectbone formationen_US
dc.titleEvaluation of bone mineral density (BMD) and indicators of bone turnover in patients with hemophiliaen_US
dc.typeArticleen_US

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