The effects of L-carnitine on some hematological parameters in rats fed a cholesterol-rich diet
Küçük Resim Yok
Tarih
2014
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TAYLOR & FRANCIS LTD
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We evaluated the effects of L-carnitine on the hematological characteristics of rats fed a cholesterol-rich diet. Healthy male Wistar Albino rats were assigned to four equal groups. During the 40 day experiment, group 1 was fed standard rat pellets, group 2 was fed standard rat pellets containing 7.5 % cholesterol powder, group 3 was fed standard rat pellets and water that contained 75 mg/l L-carnitine, and group 4 was fed standard rat pellets that contained 7.5% cholesterol and water that contained 75 mg/l L-carnitine. Blood samples were analyzed for red (RBC) and white (WBC) blood cells, hemoglobin, hematocrit, granulocytes, lymphocytes, monocytes, mean cell volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) using an automated cell counter. The RBC count in the group that received the 7.5% cholesterol diet was decreased significantly compared to the other groups. The hematocrit of the cholesterol group was lower than for the L-carnitine + cholesterol and L-carnitine groups. The MCV in the cholesterol group was significantly higher than the control group. The MCH in the cholesterol group was higher than for the other groups. There was no significant difference among the groups with regard to hemoglobin, MCHC, WBCs and leukocyte types. L-carnitine appears to have beneficial effects on erythrocyte stability, erythropoiesis and hyperlipidemia.
Açıklama
Anahtar Kelimeler
cholesterol, hematological characteristics, L-carnitine, rats
Kaynak
BIOTECHNIC & HISTOCHEMISTRY
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
89
Sayı
5
