The effects of L-carnitine on some hematological parameters in rats fed a cholesterol-rich diet

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dc.contributor.authorUluisik, D.
dc.contributor.authorKeskin, E.
dc.date.accessioned2020-03-26T18:58:36Z
dc.date.available2020-03-26T18:58:36Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe evaluated the effects of L-carnitine on the hematological characteristics of rats fed a cholesterol-rich diet. Healthy male Wistar Albino rats were assigned to four equal groups. During the 40 day experiment, group 1 was fed standard rat pellets, group 2 was fed standard rat pellets containing 7.5 % cholesterol powder, group 3 was fed standard rat pellets and water that contained 75 mg/l L-carnitine, and group 4 was fed standard rat pellets that contained 7.5% cholesterol and water that contained 75 mg/l L-carnitine. Blood samples were analyzed for red (RBC) and white (WBC) blood cells, hemoglobin, hematocrit, granulocytes, lymphocytes, monocytes, mean cell volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) using an automated cell counter. The RBC count in the group that received the 7.5% cholesterol diet was decreased significantly compared to the other groups. The hematocrit of the cholesterol group was lower than for the L-carnitine + cholesterol and L-carnitine groups. The MCV in the cholesterol group was significantly higher than the control group. The MCH in the cholesterol group was higher than for the other groups. There was no significant difference among the groups with regard to hemoglobin, MCHC, WBCs and leukocyte types. L-carnitine appears to have beneficial effects on erythrocyte stability, erythropoiesis and hyperlipidemia.en_US
dc.identifier.doi10.3109/10520295.2014.892153en_US
dc.identifier.endpage397en_US
dc.identifier.issn1052-0295en_US
dc.identifier.issn1473-7760en_US
dc.identifier.issue5en_US
dc.identifier.pmid24620726en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage393en_US
dc.identifier.urihttps://dx.doi.org/10.3109/10520295.2014.892153
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31200
dc.identifier.volume89en_US
dc.identifier.wosWOS:000337900500010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofBIOTECHNIC & HISTOCHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcholesterolen_US
dc.subjecthematological characteristicsen_US
dc.subjectL-carnitineen_US
dc.subjectratsen_US
dc.titleThe effects of L-carnitine on some hematological parameters in rats fed a cholesterol-rich dieten_US
dc.typeArticleen_US

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