Leptin response to oral glucose tolerance test in obese and nonobese premenopausal women
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Dosyalar
Tarih
2005
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TAYLOR & FRANCIS INC
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The objective of this study was to investigate the serum leptin response to oral glucose stimulation in a group of obese and nonobese normotensive, normolipidemic, and glucose-tolerant Premenopausal women. Twenty-one obese (BMI: 3 7.7 +/- 63 kg/m(2)) and 14 nonbese (BMI: 21.5 +/- 1.0 kg/m(2)) age-matched, healthy premenopausal women were included in the study. Serum glucose, insulin, and leptin Levels were measured at 30 min intervals during the 120 min of an oral glucose tolerance test (OGTT). Mean serum glucose, insulin, and leptin levels were significantly higher in the obese group compared to nonobese subjects during OGTT. Except for a 120 min decrement noted in obese women, no changes occurred in serum leptin levels during oral glucose stimulation in both groups. As a conclusion, absence of a significant elevation in serum leptin levels during OGTT in our obese subjects compared to nonobese subjects may be related to their normal metabolic variables despite being abdominally obese and insulin resistant.
Açıklama
Anahtar Kelimeler
obesity, OGTT, leptin
Kaynak
ENDOCRINE RESEARCH
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
31
Sayı
1
