Characterization of T Lymphocyte Subtypes in Endotoxin-İnduced Uveitis and Effect of Pentoxifylline Treatment

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dc.contributor.authorAvunduk, Avni Murat
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorÖztekin, Esma
dc.contributor.authorBaltacı, Abdulkerim Kasım
dc.date.accessioned2020-03-26T16:38:44Z
dc.date.available2020-03-26T16:38:44Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose. The aims of the study were twofold: 1) to investigate the role of T lymphocyte subtypes in the pathogenesis of endotoxin-induced uveitis (EIU) and 2) to study the possible beneficial effect of pentoxifylline, an inhibitor of neutrophil motility, and Tumor Necrosis Factora-alpha on this disease. Methods. Forty-two inbred male Lewis rats were divided into seven equal groups. 200 m g of Escherichia coli 055: B55 lipopolysaccharide (LPS) was injected in one hind footpad of the Group 2, 3, 4, 5, 6, and 7 rats. Group 5, 6, and 7 rats also received concomitant intraperitoneal pentoxifylline (PTX) during food pad injection of LPS. Group 1 rats were used as controls with intra-peritoneal normal saline injection. Eight, 24, and 48 hours after treatment, the rats were euthanized. Neutrophil leukocyte, mononuclear cells, and CD4+, CD8+, and CD45RA+ cell infiltration in the anterior uveal tissue were determined either by hematoxylin-eosin or monoclonal antibody staining. Tumor Necrosis Factor-alpha (TNF-alpha) levels were also measured in the aqueous and blood samples. We compared the numbers of infiltrating cells in the different groups. Results. We found that peak infiltration of lymphocyte, neutrophils, and CD4+ cells occurred at 24 hours. However, CD8+ and CD45RA+ cell number reached their highest levels at 48 hours. There was no inflammatory cell infiltration in the control rats. Concomitant pentoxifylline treatment did not affect any of these parameters, although it effectively reduced TNF-alpha concentrations in the anterior chamber and the serum. Conclusion. We conclude that, 1) T lymphocytes might be involved in the pathogenesis of endotoxin-induced uveitis. 2) The potential role of pentoxifylline in the treatment of human uveitis is questionable. However, these are initial findings and need confirmation by additional studies.en_US
dc.identifier.citationAvunduk, A. M., Avunduk, M. C., Öztekin, E., Baltacı, A. K., (2002). Characterization of T Lymphocyte Subtypes in Endotoxin-İnduced Uveitis and Effect of Pentoxifylline Treatment. Current Eye Research, 24(2), 92-98. Doi: 10.1076/ceyr.24.2.92.8157
dc.identifier.doi10.1076/ceyr.24.2.92.8157en_US
dc.identifier.endpage98en_US
dc.identifier.issn0271-3683en_US
dc.identifier.issue2en_US
dc.identifier.pmid12187479en_US
dc.identifier.startpage92en_US
dc.identifier.urihttps://dx.doi.org/10.1076/ceyr.24.2.92.8157
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17899
dc.identifier.volume24en_US
dc.identifier.wosWOS:000176844600003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAvunduk, Mustafa Cihat
dc.institutionauthorÖztekin, Esma
dc.institutionauthorBaltacı, Abdulkerim Kasım
dc.language.isoenen_US
dc.publisherSwets Zeitlinger Publishersen_US
dc.relation.ispartofCurrent Eye Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectendotoxin-induced uveitisen_US
dc.subjectpentoxifyllineen_US
dc.subjectCD4+T lymphocyteen_US
dc.subjectCD8+T lymphocyteen_US
dc.subjectCD45RA+T lymphocyteen_US
dc.titleCharacterization of T Lymphocyte Subtypes in Endotoxin-İnduced Uveitis and Effect of Pentoxifylline Treatmenten_US
dc.typeArticleen_US

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