Incidence of Chromosome 8, 10, X and Y Aneuploidies in Sperm Nucleus of Infertile Men Detected by FISH

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dc.contributor.authorAcar, Hasan
dc.contributor.authorKılınç, Mehmet
dc.contributor.authorÇora, Tülin
dc.contributor.authorAktan, Murat
dc.contributor.authorTaşkapu, Hakan
dc.date.accessioned2020-03-26T16:36:16Z
dc.date.available2020-03-26T16:36:16Z
dc.date.issued2000
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe studied the frequency of aneuploidy in sperm nuclei of six infertile men with abnormal semen profile and normal karyotype, using fluorescence in situ hybridization (FISH) with DNA probes for chromosomes 8, 10, X and Y. The control group consisted of four healthy fertile men with normal karyotype and semen profiles. The purpose of this study was to determine whether there are differences between infertile male donors and control donors for: (1) the incidence of sex chromosome aneuploidy, and (2) the number of disomies for chromosomes 8, and 10 cosegregating with chromosomes X and Y. FISH analysis showed no significant differences of sex ratios of the sperm nuclei in and between infertile and control groups. The most significant abnormalities in the infertile group were clusters of sperm nuclei bearing XY and XYY. In addition, the incidence of disomic sperm nuclei for chromosomes 8 and 10 consegregating with sex chromosomes was not significantly different beween the patient and control groups, nor within them. However, the total frequency of aneuploid sperm nuclei was significantly different beween the infertile group and the control group. We observed a significant excess of sperm nuclei bearing chromosome 10 along with disomy for chromosome Y (10YY). In conclusion, our results from FISH analysis demonstrate a significantly increased frequency of aneuploidy for the sex chromosomes in sperm nuclei from infertile men. Therefore it may be concluded that infertility is a risk factor for sex chromosome aneuploidy in sperm nuclei.en_US
dc.identifier.citationAcar, H., Kılınç, M., Çora, T., Aktan, M., Taşkapu, H., (2000). Incidence of Chromosome 8, 10, X and Y Aneuploidies in Sperm Nucleus of Infertile Men Detected by FISH. Urologia Internationalis, 64(4), 202-208. Doi: 10.1159/000030531
dc.identifier.doi10.1159/000030531en_US
dc.identifier.endpage208en_US
dc.identifier.issn0042-1138en_US
dc.identifier.issue4en_US
dc.identifier.pmid11041806en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage202en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000030531
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17219
dc.identifier.volume64en_US
dc.identifier.wosWOS:000088299300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAcar, Hasan
dc.institutionauthorKılınç, Mehmet
dc.institutionauthorÇora, Tülin
dc.institutionauthorAktan, Murat
dc.institutionauthorTaşkapu, Hakan
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofUrologia Internationalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectaneuploidyen_US
dc.subjectinfertilityen_US
dc.subjectspermen_US
dc.subjectFISHen_US
dc.titleIncidence of Chromosome 8, 10, X and Y Aneuploidies in Sperm Nucleus of Infertile Men Detected by FISHen_US
dc.typeArticleen_US

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