The effects of oral liquid and intravenous glutamine on bowel adaptation in a rabbit short bowel syndrome model

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dc.contributor.authorTekin, Ahmet
dc.contributor.authorYemis, Mustafa
dc.contributor.authorKucukkartallar, Tevfik
dc.contributor.authorVatansever, Celalettin
dc.contributor.authorCakir, Murat
dc.contributor.authorYilmaz, Huseyin
dc.contributor.authorToy, Hatice
dc.date.accessioned2020-03-26T18:05:16Z
dc.date.available2020-03-26T18:05:16Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground/aims: The aim of this study was to examine whether liquid glutamine given to rabbits after resection is as effective as intravenous (iv) glutamine and to study the positive effects of glutamine on mucosal atrophy that occurs after bowel resection. Methods: Thirty rabbits with an average weight of 2500 g were used. On the third day, 30 rabbits were divided into three groups as follows: Group I (controls): bowel resection + oral total parenteral nutrition, Group II (oral liquid L-glutamine): Bowel resection + oral total paranteral nutrition + oral liquid L-glutamine, and Group III (iv L-glutamine): bowel resection + oral total paranteral nutrition + iv L-glutamine. On the postoperative 7(th) day, all subjects were sacrificed to examine intestinal adaptation indicators. Results: There was an increase in average villas height and crypt depth in Group III compared to the other groups (p=0.0001). In Group II, the villus height and crypt depth increased more than in Group I, but the difference was less significant (p=0.038). There was no significant difference between groups in terms of average goblet cell proliferation. Conclusions: In our experimental study, it was observed that the orally given L-glutamine liquid in the rabbit intestinal adaptation model prevented mucosal atrophy after 50% bowel resection and even increased mucosa mass. However, iv glutamine led to similar and even better results. Neither route of glutamine administration was determined to have an effect on goblet cell proliferation.en_US
dc.identifier.doi10.4318/tjg.2010.0094en_US
dc.identifier.endpage243en_US
dc.identifier.issn1300-4948en_US
dc.identifier.issue3en_US
dc.identifier.pmid20931426en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage236en_US
dc.identifier.urihttps://dx.doi.org/10.4318/tjg.2010.0094
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25371
dc.identifier.volume21en_US
dc.identifier.wosWOS:000283606300007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTURKISH SOC GASTROENTEROLOGYen_US
dc.relation.ispartofTURKISH JOURNAL OF GASTROENTEROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectLiquid glutamineen_US
dc.subjectiv glutamineen_US
dc.subjectbowel resectionen_US
dc.subjectbowel adaptationen_US
dc.titleThe effects of oral liquid and intravenous glutamine on bowel adaptation in a rabbit short bowel syndrome modelen_US
dc.typeArticleen_US

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