Effect of Melatonin Supplementation on Plasma Vasopressin Response to Different Conditions in Rats with Hyperthyroidism Induced by L-Thyroxine

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dc.contributor.authorMoğulkoç, Rasim
dc.contributor.authorBaltacı, Abdulkerim Kasım
dc.date.accessioned2020-03-26T17:48:01Z
dc.date.available2020-03-26T17:48:01Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe present study was performed to determine how basal, isotonic, hypertonic and hypovolemic conditions affect fluid-electrolyte balance and plasma arginine vasopressin (AVP) levels in rats with experimental hyperthyroidism supplemented with melatonin. The rats were divided into four groups of twenty-four subjects each kept under the following treatments during one month: (1) Controls; (2) treated with L-thyroxine: (3) treated with L-thyroxine and sham melatonin and (4) treated with L-thyroxine and melatonin. After this each group was further subdivided into subgroups that were subject to normal, isotonic, hypertonic and hypovolemic conditions. The plasma AVP, total triiodothyronine (TT(3)), total thyroxine (TT(4)) and melatonin levels were measured in plasma by means of a Phoenix Pharmaceutical RIA test kit. Hematocrit and osmolality levels were also determined. There were significant increases of total T3 and T4 levels in the L.-thyroxine treated groups, p<0.001. The AVP levels were also increased in groups 2 and 3, but not so in the rats treated with melatonin (p<0.001), which also showed increased plasma melatonin levels (p<0.001). These results indicate that treatment with L-thyroxine increases stimulated and non-stimulated AVP release that are inhibited by melatonin supplementation. It was also shown that AVP response to hypertonic and hypovolemic conditions was not affected by L-thyroxine treatment and/or L-thyroxine + melatonin treatment.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk University [TF 2002/089]en_US
dc.description.sponsorshipThe support of the Scientific Research Projects Coordinatorship of Selcuk University (SUBAPK, project number TF 2002/089) is greatly appreciated. The authors would like to thank Dr. Esma Oztekin for conducting the analysis of hormones.en_US
dc.identifier.citationMoğulkoç, R., Baltacı, A. K., (2010). Effect of Melatonin Supplementation on Plasma Vasopressin Response to Different Conditions in Rats with Hyperthyroidism Induced by L-Thyroxine. Regulatory Peptides, 161, 38-42. Doi:10.1016/j.regpep.2009.12.018
dc.identifier.doi10.1016/j.regpep.2009.12.018en_US
dc.identifier.endpage42en_US
dc.identifier.issn0167-0115en_US
dc.identifier.issue01.03.2020en_US
dc.identifier.pmid20079381en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage38en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.regpep.2009.12.018
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24810
dc.identifier.volume161en_US
dc.identifier.wosWOS:000277557000006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMoğulkoç, Rasim
dc.institutionauthorBaltacı, Abdulkerim Kasım
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofREGULATORY PEPTIDESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAVPen_US
dc.subjectHyperthyroid raten_US
dc.subjectMelatoninen_US
dc.subjectHyperosmolalityen_US
dc.subjectHypovolemiaen_US
dc.titleEffect of Melatonin Supplementation on Plasma Vasopressin Response to Different Conditions in Rats with Hyperthyroidism Induced by L-Thyroxineen_US
dc.typeArticleen_US

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