Comparative effects of atorvastatin 80 mg and rosuvastatin 40 mg on the levels of serum endocan, chemerin, and galectin-3 in patients with acute myocardial infarction

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dc.authorid0000-0002-6512-1327
dc.authorid0000-0003-0456-3356
dc.authorid0000-0003-2654-7621
dc.authorid0000-0003-4099-0064
dc.authorid0000-0002-8140-874X
dc.authorid0000-0003-0570-3461
dc.authorid0000-0003-3005-5232
dc.authorid0000-0003-3750-8011
dc.authorid0000-0002-0424-231X
dc.authorid0000-0003-0037-0549
dc.authorid0000-0002-8091-7737
dc.contributor.authorTunçez, Abdullah
dc.contributor.authorAltunkeser, Bülent Behlül
dc.contributor.authorÖztürk, Bahadır
dc.contributor.authorAteş, Muhammed Salih
dc.contributor.authorTezcan, Hüseyin
dc.contributor.authorAydoğan, Canan
dc.contributor.authorKırık, Emre Can
dc.contributor.authorYalçın, Ulvi
dc.contributor.authorAygül, Nazif
dc.contributor.authorDemir, Kenan
dc.contributor.authorAkyürek, Fikret
dc.date.accessioned2020-03-26T20:13:01Z
dc.date.available2020-03-26T20:13:01Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Endocan, chemerin, and galectin-3 are discrete biomarkers associated with cardiovascular diseases and acting through different pathophysiological pathways. The aim of this study is to investigate and compare the effects of high doses of atorvastatin and rosuvastatin on serum endocan, chemerin, and galectin-3 levels in patients with acute myocardial infarction (AMI). Methods: Sixty-three patients with AMI were randomized to receive atorvastatin (80 mg/day) or rosuvastatin (40 mg/day) after percutaneous revascularization. Serum levels of endocan, chemerin, and galectin-3 were evaluated at baseline and after 4-week therapy. Results: Endocan levels were not decreased statistically significantly with atorvastatin 80 mg, but rosuvastatin 40 mg markedly decreased the levels of endocan according to baseline [from 110.27 (86.03-143.69) pg/mL to 99.22 (78.30-122.87) pg/mL with atorvastatin 80 mg and from 110.73 (77.28-165.22) pg/mL to 93.40 (70.48-115.13) pg/mL with rosuvastatin 40 mg, p=0.242 for atorvastatin 80 mg and p=0.014 for rosuvastatin 40 mg]. Chemerin levels significantly decreased in both groups according to baseline [from 264.90 (196.00-525.95) ng/mL to 135.00 (105.95-225.65) ng/mL with atorvastatin 80 mg and from 309.95 (168.87-701.27) ng/mL to 121.25 (86.60-212.65) ng/mL with rosuvastatin 40 mg, p<0.001, respectively, for both groups]. Galectin-3 levels did not change markedly with atorvastatin 80 mg, but they decreased with rosuvastatin 40 mg [from 17.00 (13.10-22.25) ng/mL to 19.30 (15.25-23.45) ng/mL with atorvastatin 80 mg, p=0.721, and from 18.25 (12.82-23.82) ng/mL to 16.60 (10.60-20.15) ng/mL with rosuvastatin 40 mg, p=0.074]. There were no significant between-group differences in terms of absolute and percentage changes of endocan, chemerin, and galectin-3 at 4 weeks. Conclusion: We reported that both statins similarly decreased the endocan levels, whereas rosuvastatin seems to have more prominent effects on the reduction of the chemerin and galectin-3 levels in patients with AMI.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk Universityen_US
dc.description.sponsorshipAbstract of this article presented as poster abstract at the 23rd International Congress of Clinical Chemistry and Laboratory Medicine Congress, helded at the Durban International Convention Center in Durban, South Africa on October 22-25, 2017. This study was supported by Scientific Research Project Coordinator of Selcuk University and the founding source did not involve in study design, in the collection, analysis, and interpretation of data; in the writing of the report; in the decision to submit the article for publication.en_US
dc.identifier.citationTunçez, A., Altunkeser, B. B., Öztürk, B., Ateş, M. S., Tezcan, H., Aydoğan, C., Kırık, E. C., Yalçın, U., Aygül, N., Demir, K., Akyürek, F. (2019). Comparative Effects of Atorvastatin 80 mg and Rosuvastatin 40 mg on the Levels of Serum Endocan, Chemerin, and Galectin-3 in Patients with Acute Myocardial Infarction. Anatolian Journal of Cardiology, 22(5), 240-249.
dc.identifier.doi10.14744/AnatolJCardiol.2019.64249en_US
dc.identifier.endpage249en_US
dc.identifier.issn2149-2263en_US
dc.identifier.issn2149-2271en_US
dc.identifier.issue5en_US
dc.identifier.pmid31674929en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage240en_US
dc.identifier.urihttps://dx.doi.org/10.14744/AnatolJCardiol.2019.64249
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37601
dc.identifier.volume22en_US
dc.identifier.wosWOS:000493983800007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTunçez, Abdullah.
dc.institutionauthorAltunkeser, Bülent Behlül.
dc.institutionauthorÖztürk, Bahadır.
dc.institutionauthorAteş, Muhammed Salih.
dc.institutionauthorTezcan, Hüseyin.
dc.institutionauthorAydoğan, Canan.
dc.institutionauthorKırık, Emre Can.
dc.institutionauthorYalçın, Ulvi.
dc.institutionauthorAygül, Nazif.
dc.institutionauthorDemir, Kenan.
dc.institutionauthorAkyürek, Fikret.
dc.language.isoenen_US
dc.publisherTURKISH SOC CARDIOLOGYen_US
dc.relation.ispartofANATOLIAN JOURNAL OF CARDIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectatorvastatinen_US
dc.subjectchemerinen_US
dc.subjectendocanen_US
dc.subjectgalectin-3en_US
dc.subjectmyocardial infarctionen_US
dc.subjectrosuvastatinen_US
dc.titleComparative effects of atorvastatin 80 mg and rosuvastatin 40 mg on the levels of serum endocan, chemerin, and galectin-3 in patients with acute myocardial infarctionen_US
dc.typeArticleen_US

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