Methylenetetrahydrofolate Reductase Gene Polymorphisms in Children with Attention Deficit Hyperactivity Disorder
Küçük Resim Yok
Tarih
2011
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
IVYSPRING INT PUBL
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: The purpose of this study was to evaluate the relationship between 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and Attention Deficit Hyperactivity Disorder (ADHD) in a sample of Turkish children. Study Design: MTHFR gene polymorphisms were assessed in 40 patients with ADHD and 30 healty controls. Two mutations in the MTHFR gene were investigated using polymerase chain reactions and restriction fragment length polymorphisms. Results: Although there were no statistically significant differences in genotype distributions of the C677T alleles between the ADHD and the control groups (p=0,678) but the genotypic pattern of the distributions of the A1298C alleles was different between the ADHD patients and the controls (p=0,033). Conclusions: Preliminary data imply a possible relationship between A1298C MTHFR polymorphisms and the ADHD.
Açıklama
Anahtar Kelimeler
Attention deficit-hyperactivity disorder, methylenetetrahydrofolate reductase gene polymorphism, folic acide
Kaynak
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
WoS Q Değeri
Q1
Scopus Q Değeri
Q2
Cilt
8
Sayı
7
