Pharmacokinetics and Oral Bioavailability of Enrofloxacin in Faunated and Defaunated Angora Goats
Küçük Resim Yok
Tarih
2000
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ecole National Vet Toulouse
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The pharmacokinetic properties and bioavailability of enrofloxacin were compared after single oral administration of 5 mg/kg bw to faunated and defaunated adult Angora goats. Plasma enrofloxacin concentrations were measured by high performance liquid chromatography. The pharmacokinetic data were best described by a 2-compartment open model and were similar in both groups. The plasma concentrations of enrofloxacin in defaunated group were higher than those of faunated group except for 8, 12 and 24 hours, and C-max in defaunated goats was also higher than other group (p < 0.05). Although the oral bioavailability of the drug in defaunated group (F, 30 %) was higher than that in the faunated group (F, 23 %), this difference was not significant (p > 0.05). In conclusion, oral absorption of enrofloxacin in adult angora goats was slightly affected by defaunation. Despite of low oral bioavailability, once daily oral administration of enrofloxacin at the dose of 5 mg/kg bw may be suitable in treatment of infectious diseases caused by sensitive pathogens in Angora goats.
Açıklama
Anahtar Kelimeler
enrofloxacin, pharmacokinetics, defaunation, Angora goats
Kaynak
Revue De Medecine Veterinaire
WoS Q Değeri
Q2
Scopus Q Değeri
Q3
Cilt
151
Sayı
6
Künye
Eryavuz, A., Baş, A. L., Traş, B., Yazar, E., Elmas, M., (2000). Pharmacokinetics and Oral Bioavailability of Enrofloxacin in Faunated and Defaunated Angora Goats. Revue De Medecine Veterinaire, 151(6), 507-510.
