Pharmacokinetics and Oral Bioavailability of Enrofloxacin in Faunated and Defaunated Angora Goats

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dc.contributor.authorElmas, M.
dc.contributor.authorYazar, E.
dc.contributor.authorTraş, B.
dc.contributor.authorBaş, A. L.
dc.contributor.authorEryavuz, A.
dc.date.accessioned2020-03-26T16:36:17Z
dc.date.available2020-03-26T16:36:17Z
dc.date.issued2000
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe pharmacokinetic properties and bioavailability of enrofloxacin were compared after single oral administration of 5 mg/kg bw to faunated and defaunated adult Angora goats. Plasma enrofloxacin concentrations were measured by high performance liquid chromatography. The pharmacokinetic data were best described by a 2-compartment open model and were similar in both groups. The plasma concentrations of enrofloxacin in defaunated group were higher than those of faunated group except for 8, 12 and 24 hours, and C-max in defaunated goats was also higher than other group (p < 0.05). Although the oral bioavailability of the drug in defaunated group (F, 30 %) was higher than that in the faunated group (F, 23 %), this difference was not significant (p > 0.05). In conclusion, oral absorption of enrofloxacin in adult angora goats was slightly affected by defaunation. Despite of low oral bioavailability, once daily oral administration of enrofloxacin at the dose of 5 mg/kg bw may be suitable in treatment of infectious diseases caused by sensitive pathogens in Angora goats.en_US
dc.identifier.citationEryavuz, A., Baş, A. L., Traş, B., Yazar, E., Elmas, M., (2000). Pharmacokinetics and Oral Bioavailability of Enrofloxacin in Faunated and Defaunated Angora Goats. Revue De Medecine Veterinaire, 151(6), 507-510.
dc.identifier.endpage510en_US
dc.identifier.issn0035-1555en_US
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage507en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17234
dc.identifier.volume151en_US
dc.identifier.wosWOS:000088551100005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEcole National Vet Toulouseen_US
dc.relation.ispartofRevue De Medecine Veterinaireen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectenrofloxacinen_US
dc.subjectpharmacokineticsen_US
dc.subjectdefaunationen_US
dc.subjectAngora goatsen_US
dc.titlePharmacokinetics and Oral Bioavailability of Enrofloxacin in Faunated and Defaunated Angora Goatsen_US
dc.typeArticleen_US

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