Utilisation of Rhododendron luteum Sweet bioactive compounds as valuable source of enzymes inhibitors, antioxidant, and anticancer agents
Yükleniyor...
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
PERGAMON-ELSEVIER SCIENCE LTD
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Ethnobotanical evidences report the use of Rhododendron luteum Sweet (Ericaceae) in traditional medicinal systems. However, R. luteum has been associated to the occurrence of 'mad honey' poisoning. In the present study, the ethyl acetate, methanol, and water extracts of R. luteum were investigated for their in vitro antioxidant, enzyme inhibition, and cytotoxic properties. The cytotoxicity of R. luteum extracts on A549 lung cancer cell line was evaluated using MTT cell viability assay. Besides, HPLC-ESI-MSn approach was employed to elucidate the secondary metabolite profiles of R. luteum in order to establish any structure-activity relationship. Methanol and water extracts of R. luteum possessed highest radical scavenging and reducing properties while the ethyl acetate extract showed highest metal chelating properties. In terms of enzyme inhibition, the methanol and ethyl acetate extracts of R. luteum, possessing epigallocatechin, were active inhibitors of cholinesterase enzymes, a-glucosidase, and tyrosinase. Water extract caused growth inhibition of A549 cells with 207.2 mu g/ml IC50 value. Though R. luteum has received little scientific attention due to the occurrence of grayanotoxins in the plant, however, data presented in this work shows promising biological activity of R. luteum and highlighted its role as a potential source of antioxidant and key enzyme inhibitors.
Açıklama
10th International Symposium on Natural Products Chemistry and Applications (ISNPCA) -- 2019 -- Chillan, CHILE
Anahtar Kelimeler
Yellow azalea, Honeysuckle azalea, Enzyme inhibitory, Anticancer, PCA analysis
Kaynak
FOOD AND CHEMICAL TOXICOLOGY
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
135
Sayı
Künye
Mahomoodally, M. F., Sieniawska, E., Sinan, K. I., Picot-Allain, M. C. N., Yerlikaya, Ş., Baloğlu, M. C., Altunoğlu, Y. C., Şenkardeş, I., Rengasamy, K. R. R., Zengin, G. (2020). Utilisation of Rhododendron luteum Sweet Bioactive Compounds as Valuable Source of Enzymes Inhibitors, Antioxidant, and Anticancer Agents. Food and Chemical Toxicology, 135(0), 1-9.
