Utilisation of Rhododendron luteum Sweet bioactive compounds as valuable source of enzymes inhibitors, antioxidant, and anticancer agents

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dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorSieniawska, Elwira
dc.contributor.authorSinan, Kouadio Ibrahime
dc.contributor.authorPicot-Allain, Marie Carene Nancy
dc.contributor.authorYerlikaya, Şerife
dc.contributor.authorBaloğlu, Mehmet Cengiz
dc.contributor.authorAltunoğlu, Yasemin Çelik
dc.contributor.authorŞenkardeş, İsmail
dc.contributor.authorRengasamy, Kannan R. R.
dc.contributor.authorZengin, Gökhan
dc.date.accessioned2020-03-26T20:20:37Z
dc.date.available2020-03-26T20:20:37Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description10th International Symposium on Natural Products Chemistry and Applications (ISNPCA) -- 2019 -- Chillan, CHILEen_US
dc.description.abstractEthnobotanical evidences report the use of Rhododendron luteum Sweet (Ericaceae) in traditional medicinal systems. However, R. luteum has been associated to the occurrence of 'mad honey' poisoning. In the present study, the ethyl acetate, methanol, and water extracts of R. luteum were investigated for their in vitro antioxidant, enzyme inhibition, and cytotoxic properties. The cytotoxicity of R. luteum extracts on A549 lung cancer cell line was evaluated using MTT cell viability assay. Besides, HPLC-ESI-MSn approach was employed to elucidate the secondary metabolite profiles of R. luteum in order to establish any structure-activity relationship. Methanol and water extracts of R. luteum possessed highest radical scavenging and reducing properties while the ethyl acetate extract showed highest metal chelating properties. In terms of enzyme inhibition, the methanol and ethyl acetate extracts of R. luteum, possessing epigallocatechin, were active inhibitors of cholinesterase enzymes, a-glucosidase, and tyrosinase. Water extract caused growth inhibition of A549 cells with 207.2 mu g/ml IC50 value. Though R. luteum has received little scientific attention due to the occurrence of grayanotoxins in the plant, however, data presented in this work shows promising biological activity of R. luteum and highlighted its role as a potential source of antioxidant and key enzyme inhibitors.en_US
dc.identifier.citationMahomoodally, M. F., Sieniawska, E., Sinan, K. I., Picot-Allain, M. C. N., Yerlikaya, Ş., Baloğlu, M. C., Altunoğlu, Y. C., Şenkardeş, I., Rengasamy, K. R. R., Zengin, G. (2020). Utilisation of Rhododendron luteum Sweet Bioactive Compounds as Valuable Source of Enzymes Inhibitors, Antioxidant, and Anticancer Agents. Food and Chemical Toxicology, 135(0), 1-9.
dc.identifier.doi10.1016/j.fct.2019.111052en_US
dc.identifier.issn0278-6915en_US
dc.identifier.issn1873-6351en_US
dc.identifier.pmid31837349en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.fct.2019.111052
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38628
dc.identifier.volume135en_US
dc.identifier.wosWOS:000509791400046en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSinan, Kouadio Ibrahime
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofFOOD AND CHEMICAL TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectYellow azaleaen_US
dc.subjectHoneysuckle azaleaen_US
dc.subjectEnzyme inhibitoryen_US
dc.subjectAnticanceren_US
dc.subjectPCA analysisen_US
dc.titleUtilisation of Rhododendron luteum Sweet bioactive compounds as valuable source of enzymes inhibitors, antioxidant, and anticancer agentsen_US
dc.typeArticleen_US

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