Plasmid-mediated fluoroquinolone resistance in clinical isolates of escherichia coli in Konya, Turkey

Basit Öğe Kaydı
dc.contributor.authorAzeez, Dhay Ali
dc.contributor.authorFindik, Duygu
dc.contributor.authorDagi, Hatice Turk
dc.contributor.authorArslan, Ugur
dc.date.accessioned2020-03-26T19:55:12Z
dc.date.available2020-03-26T19:55:12Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü en_US
dc.description.abstractPurpose: Resistance to quinolones usually results from mutations in the topoisomerase genes encoded chromosomally and also the expression of efflux pumps, loss of porines and the transfer of plasmid-mediated genes. The aim of this study was to investigate the presence of plasmid-mediated quinolones resistance genes (qnrA, qnrB, qnrC, qnrS, qepA, and aac(6')-1b-cr) in clinical isolates of Esherichia coli from Selcuk University, Konya, Turkey. Materials and Methods: In this study 115 quinolone-resistant isolates were screened for qnrA, qnrB, qnrC, qnrS, qepA, and aac(6')-1b-cr genes by polymerase chain reaction (PCR). All aac(6')-1b positive amplicons were analyzed by digestion with BseGI restriction enzyme to identify aac(6')-1b-cr variant. Results: Of the 115 quinolone-resistant E. coli strains, three (2.6%) carried qnrB, nine (7.8%) carried qnrS and 50 (43.5%) carried aac(6')-1b-cr genes. None of them harboured qnrA, qnrC and qepA genes. Conclusion: We determined that aac(6')-1b-cr gene was responsible for most of the quinolone-resistant E. coli strains from Konya, Turkey. The prevalence of qnrB and qnrS genes was low and qnrA, qnrC and qepA genes were not detected. The surveillance of quinolone resistance genes is important, especially plasmid mediated ones are rapidly spreading all over the world.en_US
dc.description.sponsorshipSelcuk University Scientific Research Projects CoordinatorshipSelcuk University [14202010]en_US
dc.description.sponsorshipThis study was supported by Selcuk University Scientific Research Projects Coordinatorship with project number 14202010.en_US
dc.identifier.citationAzeez, D. A., Findık, D., Dağı, H. T., Arslan, U. (2018). Plasmid-mediated fluoroquinolone resistance in clinical isolates of Escherichia coli in Konya, Turkey. Cukurova Medical Journal, 43(2), 295-300.
dc.identifier.doi10.17826/cumj.341637en_US
dc.identifier.endpage300en_US
dc.identifier.issn2602-3032en_US
dc.identifier.issn2602-3040en_US
dc.identifier.issue2en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage295en_US
dc.identifier.urihttps://dx.doi.org/10.17826/cumj.341637
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36869
dc.identifier.volume43en_US
dc.identifier.wosWOS:000437950000004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorAzeez, Dhay Ali
dc.institutionauthorFindik, Duygu
dc.institutionauthorDagi, Hatice Turk
dc.institutionauthorArslan, Ugur
dc.language.isoenen_US
dc.publisherCUKUROVA UNIV, FAC MEDICINEen_US
dc.relation.ispartofCukurova Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEscherichia colien_US
dc.subjectplasmid-mediated fluoroquinolone resistanceen_US
dc.subjectqnren_US
dc.subjectqepAen_US
dc.subjectaac(6 ')-1b-cren_US
dc.titlePlasmid-mediated fluoroquinolone resistance in clinical isolates of escherichia coli in Konya, Turkeyen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Dhay Ali AZEEZ.pdf
Boyut:
301.53 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Full Text Access
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Tıbbi Mikrobiyoloji/Makale Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu