The effects of local and intraperitoneal zinc treatments on maxillofacial fracture healing in rabbits
Yükleniyor...
Dosyalar
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Churchill Livingstone
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study aimed to determine whether administration of topical and intraperitoneal zinc formaxillofacial fractures has any impact on the bone healing process.Material and method:Thirty-two New Zealand rabbits were randomly assigned to four groups of eighteach. Thefirst group was the control group; fracture lines werefixed using titanium microplates and nomedication was administered. The second group receivedfixations using zinc-coated titanium micro-plates. A single dose of 3 mg/kg zinc was administered intraperitoneally to the third group followingfixations with titanium microplates. A single dose of 3 mg/kg zinc was administered intraperitoneally tothe fourth group followingfixations with zinc-coated titanium microplates. Zinc coating on to the ti-tanium microplates was achieved using the physical vapor deposition technique. A fracture line wascreated in the nasal bones of all subjects andfixed withfive-holeflat microplates and three 5-mm microscrews. All work groups were sacrificed at the end of the sixth week.Results:Histological examination showed that the number of osteoblasts were significantly higher inzinc-coated group (Group 2) than zinc uncoated, control group (Group 1), (415.6±46.7 vs 366.3±11.8)(p<0.001). It was observed that intraperitoneal zinc treatment alone (Group 3) did not significantlyincrease in the osteoblast count compared to zinc un-coated group (Group 1), (390.6±83.2 vs366.3±11.8), (p¼0.341). The immunoreactivity scores for IGF-1 were significantly higher in the zinc-coated group compared to control group (Group 2 vs 1), (9.3±2.8 vs 3.7±1.9) (p<0.05). It wasobserved that intraperitoneal zinc treatment did not cause a significant difference in the aspect of IGF-1for zinc-coated groups (Group 2 vs 4) (9.3±2.8 vs 9.6±2.2) (p¼0.791). The difference in the immu-noreactivity score among whole groups for TGF-bwas not statistically significant (Group 1 vs 2, 3.2±1.7vs 4.4±2.3, p¼0.256; Group 1 vs 3, 3.2±1.7 vs 3.8±2.8, p¼0.524; Group 1 vs 4, 3.2±1.7 vs 2.8±1.3,p¼0.717; Group 2 vs 3, 4.4±2.3, vs 3.8±2.8, p¼0.610; Group 2 vs 4, 4.4±2.3, vs 2.8±1.3, p¼0.124;Group 3 vs 4, 3.8±2.8, vs 2.8±1.3, p¼0.311).Conclusion:The local use of titanium microplates coated with zinc by PVD technique was found effectivefor fracture healing. Zinc coating of titanium microplates used in fracture treatment can acceleratefracture healing. It may be concluded that clinical studies should be performed now in order to explore ifcomparable results can be achieved in humans.
Açıklama
Anahtar Kelimeler
Fracture healing, IGF-1, Maxillofacial trauma, TGF- ?, Zinc
Kaynak
Journal of Cranio-Maxillofacial Surgery
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
48
Sayı
3
Künye
Azgın, İ., Arbağ, H., Eryılmaz, M.A., Çelik, Z. E. (2020). The Effects Of Local And Intraperitoneal Zinc Treatments On Maxillofacial Fracture Healing In Rabbits. Journal of Cranio-Maxillofacial Surgery, 48,(3), 261-267.
