The effects of local and intraperitoneal zinc treatments on maxillofacial fracture healing in rabbits

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dc.contributor.authorAzgın, İsa
dc.contributor.authorArbağ, Hamdi
dc.contributor.authorEryılmaz, Mehmet Akif
dc.contributor.authorÇelik, Zeliha Esin
dc.date.accessioned2020-03-26T20:20:57Z
dc.date.available2020-03-26T20:20:57Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractThis study aimed to determine whether administration of topical and intraperitoneal zinc formaxillofacial fractures has any impact on the bone healing process.Material and method:Thirty-two New Zealand rabbits were randomly assigned to four groups of eighteach. Thefirst group was the control group; fracture lines werefixed using titanium microplates and nomedication was administered. The second group receivedfixations using zinc-coated titanium micro-plates. A single dose of 3 mg/kg zinc was administered intraperitoneally to the third group followingfixations with titanium microplates. A single dose of 3 mg/kg zinc was administered intraperitoneally tothe fourth group followingfixations with zinc-coated titanium microplates. Zinc coating on to the ti-tanium microplates was achieved using the physical vapor deposition technique. A fracture line wascreated in the nasal bones of all subjects andfixed withfive-holeflat microplates and three 5-mm microscrews. All work groups were sacrificed at the end of the sixth week.Results:Histological examination showed that the number of osteoblasts were significantly higher inzinc-coated group (Group 2) than zinc uncoated, control group (Group 1), (415.6±46.7 vs 366.3±11.8)(p<0.001). It was observed that intraperitoneal zinc treatment alone (Group 3) did not significantlyincrease in the osteoblast count compared to zinc un-coated group (Group 1), (390.6±83.2 vs366.3±11.8), (p¼0.341). The immunoreactivity scores for IGF-1 were significantly higher in the zinc-coated group compared to control group (Group 2 vs 1), (9.3±2.8 vs 3.7±1.9) (p<0.05). It wasobserved that intraperitoneal zinc treatment did not cause a significant difference in the aspect of IGF-1for zinc-coated groups (Group 2 vs 4) (9.3±2.8 vs 9.6±2.2) (p¼0.791). The difference in the immu-noreactivity score among whole groups for TGF-bwas not statistically significant (Group 1 vs 2, 3.2±1.7vs 4.4±2.3, p¼0.256; Group 1 vs 3, 3.2±1.7 vs 3.8±2.8, p¼0.524; Group 1 vs 4, 3.2±1.7 vs 2.8±1.3,p¼0.717; Group 2 vs 3, 4.4±2.3, vs 3.8±2.8, p¼0.610; Group 2 vs 4, 4.4±2.3, vs 2.8±1.3, p¼0.124;Group 3 vs 4, 3.8±2.8, vs 2.8±1.3, p¼0.311).Conclusion:The local use of titanium microplates coated with zinc by PVD technique was found effectivefor fracture healing. Zinc coating of titanium microplates used in fracture treatment can acceleratefracture healing. It may be concluded that clinical studies should be performed now in order to explore ifcomparable results can be achieved in humans.en_US
dc.description.sponsorship121518016en_US
dc.description.sponsorshipThis work was supported by the Necmettin Erbakan University , Medical Faculty [Grant Number: 121518016 ].en_US
dc.identifier.citationAzgın, İ., Arbağ, H., Eryılmaz, M.A., Çelik, Z. E. (2020). The Effects Of Local And Intraperitoneal Zinc Treatments On Maxillofacial Fracture Healing In Rabbits. Journal of Cranio-Maxillofacial Surgery, 48,(3), 261-267.
dc.identifier.doi10.1016/j.jcms.2020.01.013en_US
dc.identifier.endpage267en_US
dc.identifier.issn1010-5182en_US
dc.identifier.issue3en_US
dc.identifier.pmid32046897en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage261en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jcms.2020.01.013
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38708
dc.identifier.volume48en_US
dc.identifier.wosWOS:000519968900012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇelik, Zeliha Esin
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofJournal of Cranio-Maxillofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectFracture healingen_US
dc.subjectIGF-1en_US
dc.subjectMaxillofacial traumaen_US
dc.subjectTGF- ?en_US
dc.subjectZincen_US
dc.titleThe effects of local and intraperitoneal zinc treatments on maxillofacial fracture healing in rabbitsen_US
dc.typeArticleen_US

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