The relationship between the findings of vestibular evoked myogenic potentials and severity of obstructive sleep apnea syndrome

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dc.authorid0000-0001-7643-7100
dc.authorid0000-0002-0075-7770
dc.authorid0000-0001-9804-7023
dc.authorid0000-0002-3153-3294
dc.authorid0000-0003-0667-034X
dc.authorid0000-0001-9524-6115
dc.authorid0000-0002-5595-7251
dc.contributor.authorUlusoy, Bülent.
dc.contributor.authorGül, Osman.
dc.contributor.authorElsürer, Çagdaş.
dc.contributor.authorBozkurt, Mete Kaan.
dc.contributor.authorTülek, Baykal.
dc.contributor.authorKörez, Muslu Kazım.
dc.contributor.authorEkmekçi, Hakan.
dc.contributor.authorÇolpan, Bahar.
dc.date.accessioned2020-03-26T20:20:35Z
dc.date.available2020-03-26T20:20:35Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose Our study aimed to evaluate the effects of chronic hypoxic state in Obstructive Sleep Apnea Syndrome (OSAS) on brainstem pathways using Vestibular Evoked Myogenic Potential (VEMP) test and to investigate the presence of new markers likely to be correlated with the severity of the disease. Methods The study was planned as prospective and double blind. A total of 60 patients (120 ears) diagnosed with mild, moderate and severe OSAS were included in the study and the patients are grouped as 20 patients in each group. Twenty volunteer healthy individuals (40 ears) shown to be without OSAS were included in the study. VEMP measurements were made in 60 study group patients (120 ears) and in 20 healthy controls (40 ears). The groups were compared in terms of variables such as the acquisition rate of oVEMP and cVEMP waves, interval between the waves, latency and amplitude of the waves. p < 0.05 values were considered as significant. Results The results of cVEMP test showed that the rate of wave acquisition in the moderate and severe OSAS groups was significantly lower than the control group and mild OSAS groups (p = 0.008). There was no difference between the control group and the mild OSAS group in terms of the rate of obtaining the wave (p > 0.05). In the moderate and severe OSAS groups, P1N1 amplitude and N1P2 amplitude values were found to be significantly lower than the mild OSAS group (p = 0.007 and p = 0.017, respectively). In the oVEMP test, there was no significant difference between the mild OSAS group and the control group in terms of the wave yield (p > 0.05); however, it was found that the rate of wave acquisition in the moderate and severe OSAS groups was significantly lower than the mild OSAS group (p = 0.041). There was inverse correlation between the N1P2 interval and P1N1 amplitude value and AHI in simple regression analysis and multiple regression analysis (p = 0.012 and p = 0.021; p = 0.009 and p = 0.040, respectively). Conclusion The negative effects of chronic intermittent hypoxia related with OSAS on the brainstem and vestibular system can be demonstrated by VEMP tests. Especially, the inability to obtain the wave is the most important finding showing this situation. Also, we think that N1P2 interval and P1N1 amplitude markers can be used to detect the subclinical negative effect of chronic hypoxia on vestibular nuclei in the brainstem.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk University [18401106]en_US
dc.description.sponsorshipFinancial support was received from Selcuk University (Project number; 18401106).en_US
dc.identifier.citationUlusoy, B., Gül, O., Elsürer, Ç., Bozkurt, M. K., Tülek, B., Körez, M. K., Ekmekçi, H., Çolpan, B. (2020). The Relationship Between the Findings of Vestibular Evoked Myogenic Potentials and Severity of Obstructive Sleep Apnea Syndrome. European Archives of Oto-Rhino-Laryngology, 277(1), 37–46.
dc.identifier.doi10.1007/s00405-019-05654-8en_US
dc.identifier.endpage46en_US
dc.identifier.issn0937-4477en_US
dc.identifier.issn1434-4726en_US
dc.identifier.issue1en_US
dc.identifier.pmid31542832en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage37en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00405-019-05654-8
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38622
dc.identifier.volume277en_US
dc.identifier.wosWOS:000511653200005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUlusoy, Bülent.
dc.institutionauthorGül, Osman.
dc.institutionauthorElsürer, Çagdaş.
dc.institutionauthorBozkurt, Mete Kaan.
dc.institutionauthorTülek, Baykal.
dc.institutionauthorKörez, Muslu Kazım.
dc.institutionauthorEkmekçi, Hakan.
dc.institutionauthorÇolpan, Bahar.
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofEUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectObstructive sleep apnea syndromeen_US
dc.subjectCervical vestibular evoked myogenic potentialsen_US
dc.subjectOcular vestibular evoked myogenic potentialsen_US
dc.subjectHypoxiaen_US
dc.subjectBrainstemen_US
dc.titleThe relationship between the findings of vestibular evoked myogenic potentials and severity of obstructive sleep apnea syndromeen_US
dc.typeArticleen_US

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