An assessment of the nutraceutical potential of Juglans regia L.leaf powder in diabetic rats

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dc.contributor.authorMollica, Adriano
dc.contributor.authorZengin, Gökhan
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorStefariucci, Azzurra
dc.contributor.authorMacedonio, Giorgia
dc.contributor.authorBellagamba, Giuseppe
dc.contributor.authorOnaolapo, Olakunle
dc.date.accessioned2020-03-26T19:33:46Z
dc.date.available2020-03-26T19:33:46Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, we evaluated the nutraceutical potential of juglans regia L (a dietary supplement and food additive) by evaluating the in-vitro anti-diabetic potential and by assessing the in-vivo anti hyperglycaemic, anti-hyperlipidaemic, and organ-protective effects of freshly-dried and powdered leaves of J. regia L in diabetic rats. In the in-vivo experiments, dry powder of J. regia L leaf (25, 50 and 100 mg/kg) was administered orally, twice daily (9.00 a.m. and 5 p.m.) to streptozocin-induced diabetic rats over a period of 28 days, during which body weight and blood glucose were monitored weekly. At the end of the experimental period, animals were sacrificed, blood was taken for assessment of lipid profile, antioxidant activity and liver/kidney biochemistry; while samples of the pancreas, liver and kidneys were fixed, processed, sectioned, and stained for general histology. Phytochemical evaluations of three extracts were carried out using HPLC-PDA validated procedures, while enzyme-inhibitory potentials were tested against alpha-amylase and alpha-glucosidase. In-vivo assays showed that twice-daily administration of J. regia L leaf resulted in weight gain, glycaemic control, reversal of dyslipidaemia and biochemical evidences of liver/kidney injury, and protection against pancreas, liver and kidney tissue injury. (C) 2017 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.fct.2017.03.056en_US
dc.identifier.endpage564en_US
dc.identifier.issn0278-6915en_US
dc.identifier.issn1873-6351en_US
dc.identifier.pmid28366844en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage554en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.fct.2017.03.056
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34780
dc.identifier.volume107en_US
dc.identifier.wosWOS:000408596500004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofFOOD AND CHEMICAL TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHPLC-PDAen_US
dc.subjectPolyphenolsen_US
dc.subjectFlavonoidsen_US
dc.subjectJuglans regia Len_US
dc.subjectDiabetesen_US
dc.titleAn assessment of the nutraceutical potential of Juglans regia L.leaf powder in diabetic ratsen_US
dc.typeArticleen_US

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