Multidirectional biological investigation and phytochemical profile of Rubus sanctus and Rubus ibericus
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
PERGAMON-ELSEVIER SCIENCE LTD
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In the present study, the biological properties, including, the enzyme inhibitory and antioxidant activities, as well as, the phytochemical profile of the ethyl acetate, methanol, and water extracts of Rubus sanctus Schreb. and Rubus ibericus Juz. leaves were determined using in vitro bioassays. Wide range of phytochemicals, including, hydroxybenzoic acids, hydroxycinnamic acids, acylquinic acids, ellagitannins, flavonoids, and triterpenoid saponins were determined using UHPLC-ESI/HRMS technique. The ethyl acetate and methanol extracts of the studied Rubus species effectively inhibited acetyl and butyryl cholinesterase. On the other hand, R. sanctus water extract showed low inhibition against alpha-amylase and prominent inhibitory action against alpha-glucosidase. Data collected from this study reported the radical scavenging and reducing potential of the studied Rubus species. Investigation of the protective effects of the different extracts of R. sanctus and R. ibericus in experimental model of ulcerative colitis was performed. The extracts were also tested on spontaneous migration of human colon cancer cells (HCT116) in wound healing experimental paradigm. Only R. sanctus methanol extract inhibited spontaneous HCT116 migration in the wound healing test. Our results suggested that R. sanctus and R. ibericus may be potential candidates as sources of biologically-active compounds for the development of nutraceuticals, pharmaceuticals, and/or cosmetics.
Açıklama
1st International Conference on Natural Toxicology and Pharmacology (ICNTP) -- AUG 08-12, 2019 -- Guangzhou, PEOPLES R CHINA
Anahtar Kelimeler
Rubus, LC-MS, Toxicity, Antioxidant, Anti-inflammatory, Wound healing
Kaynak
FOOD AND CHEMICAL TOXICOLOGY
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
127
Sayı
Künye
Zengin, G., Ferrante, C., Senkardes, I., Gevrenova, R., Zheleva-Dimitrova, D., Menghini, L., Orlando, G., Recinella, L., Chiavaroli, A., Leone, S., Brunetti, L., Picot-Allain, C. M. N., Rengasamy, K. R. R., Mahomoodally, M. F. (2019). Multidirectional Biological İnvestigation And Phytochemical Profile Of Rubus Sanctus And Rubus İbericus. Food And Chemical Toxicology, 127, 237-250.
