Multidirectional biological investigation and phytochemical profile of Rubus sanctus and Rubus ibericus

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorFerrante, Claudio
dc.contributor.authorSenkardes, Ismail
dc.contributor.authorGevrenova, Reneta
dc.contributor.authorZheleva-Dimitrova, Dimitrina
dc.contributor.authorMenghini, Luigi
dc.contributor.authorOrlando, Giustino
dc.contributor.authorRecinella, Lucia
dc.contributor.authorChiavaroli, Annalisa
dc.contributor.authorLeone, Sheila
dc.contributor.authorBrunetti, Luigi
dc.contributor.authorPicot-Allain, Carene Marie Nancy
dc.contributor.authorRengasamy, Kannan RR.
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2020-03-26T20:15:18Z
dc.date.available2020-03-26T20:15:18Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description1st International Conference on Natural Toxicology and Pharmacology (ICNTP) -- AUG 08-12, 2019 -- Guangzhou, PEOPLES R CHINAen_US
dc.description.abstractIn the present study, the biological properties, including, the enzyme inhibitory and antioxidant activities, as well as, the phytochemical profile of the ethyl acetate, methanol, and water extracts of Rubus sanctus Schreb. and Rubus ibericus Juz. leaves were determined using in vitro bioassays. Wide range of phytochemicals, including, hydroxybenzoic acids, hydroxycinnamic acids, acylquinic acids, ellagitannins, flavonoids, and triterpenoid saponins were determined using UHPLC-ESI/HRMS technique. The ethyl acetate and methanol extracts of the studied Rubus species effectively inhibited acetyl and butyryl cholinesterase. On the other hand, R. sanctus water extract showed low inhibition against alpha-amylase and prominent inhibitory action against alpha-glucosidase. Data collected from this study reported the radical scavenging and reducing potential of the studied Rubus species. Investigation of the protective effects of the different extracts of R. sanctus and R. ibericus in experimental model of ulcerative colitis was performed. The extracts were also tested on spontaneous migration of human colon cancer cells (HCT116) in wound healing experimental paradigm. Only R. sanctus methanol extract inhibited spontaneous HCT116 migration in the wound healing test. Our results suggested that R. sanctus and R. ibericus may be potential candidates as sources of biologically-active compounds for the development of nutraceuticals, pharmaceuticals, and/or cosmetics.en_US
dc.description.sponsorshipJinan Univ, Zhejiang Univ, Univ Macau, Univ Hong Kong, Int Assoc Dietet Nutr & Safety, Int Soc Chinese Meden_US
dc.description.sponsorshipItalian Ministry of University (FAR)en_US
dc.description.sponsorshipThe study was supported by Italian Ministry of University (FAR grants): FAR 2018 granted to Prof. Claudio Ferrante; FAR 2017 granted to Prof. Giustino Orlando.en_US
dc.identifier.citationZengin, G., Ferrante, C., Senkardes, I., Gevrenova, R., Zheleva-Dimitrova, D., Menghini, L., Orlando, G., Recinella, L., Chiavaroli, A., Leone, S., Brunetti, L., Picot-Allain, C. M. N., Rengasamy, K. R. R., Mahomoodally, M. F. (2019). Multidirectional Biological İnvestigation And Phytochemical Profile Of Rubus Sanctus And Rubus İbericus. Food And Chemical Toxicology, 127, 237-250.
dc.identifier.doi10.1016/j.fct.2019.03.041en_US
dc.identifier.endpage250en_US
dc.identifier.issn0278-6915en_US
dc.identifier.issn1873-6351en_US
dc.identifier.pmid30914354en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage237en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.fct.2019.03.041
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38014
dc.identifier.volume127en_US
dc.identifier.wosWOS:000467512200027en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gokhan
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofFOOD AND CHEMICAL TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectRubusen_US
dc.subjectLC-MSen_US
dc.subjectToxicityen_US
dc.subjectAntioxidanten_US
dc.subjectAnti-inflammatoryen_US
dc.subjectWound healingen_US
dc.titleMultidirectional biological investigation and phytochemical profile of Rubus sanctus and Rubus ibericusen_US
dc.typeArticleen_US

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