Immunohistochemical Analysis of CD45RO(+) T Cells and Vascular Endothelial Growth Factor Expression in Cyclosporin A-Induced Rat Gingival Tissue
Yükleniyor...
Dosyalar
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: The aim of this study is to evaluate CD4(+), CD8(+), and CD45RO(+) T cells, and vascular endothelial growth factor (VEGF) expression in cyclosporin A (CsA) induced rat overgrown gingival tissue during an 8-week period. Methods: Sixty male Sprague-Dawley rats weighing 200 to 250 g were used in this study. Mandibular first molars were ligated with 3-0 silk suture. The rats received daily doses of 0.09% NaCl (control group) or 10 mg/kg body weight of CsA (test group) by intraperitoneal injections. Five rats from the control group and 10 rats from the test group were sacrificed at each experimental period (2, 4, 6, and 8 weeks after the beginning of CsA treatment). The specimens were examined immunohistochemically. Results: CD4(+), CD8(+), and CD45RO(+) T cells, and VEGF expression were more prevalent in the CsA-treated group than in the control group (P <0.05). VEGF was significantly correlated with CD4(+) T cells, CD4(+)/CD8(+) ratio, and CD45RO(+) cells (P<0.05). Conclusion: Based on our findings, we conclude that VEGF, a major regulator of angiogenesis, and CD4(+), CD8(+), and CD45RO(+) memory T cells play a key role in CsA-induced gingival overgrowth. J Periodontol 2012;83:248-255.
Açıklama
Anahtar Kelimeler
CD4 antigen, CD45RO antigen, models, animal, vascular endothelial growth factor A
Kaynak
Journal of Periodontology
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
83
Sayı
2
Künye
Alptekin, N. O., Ustun, K., Yaprak, E., Avunduk, M. C., Ataoglu, T., (2012). Immunohistochemical Analysis
of CD45RO+ T Cells and Vascular
Endothelial Growth Factor Expression
in Cyclosporin A–Induced
Rat Gingival Tissue. Journal of Periodontol. 83(2), 248-255. doi: 10.1902/jop.2011.110034.
