Immunohistochemical Analysis of CD45RO(+) T Cells and Vascular Endothelial Growth Factor Expression in Cyclosporin A-Induced Rat Gingival Tissue

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dc.contributor.authorAlptekin, Nilgün Özlem
dc.contributor.authorÜstün, Kemal
dc.contributor.authorYaprak, Emre
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorAtaoğlu, Tamer
dc.date.accessioned2020-03-26T18:30:42Z
dc.date.available2020-03-26T18:30:42Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The aim of this study is to evaluate CD4(+), CD8(+), and CD45RO(+) T cells, and vascular endothelial growth factor (VEGF) expression in cyclosporin A (CsA) induced rat overgrown gingival tissue during an 8-week period. Methods: Sixty male Sprague-Dawley rats weighing 200 to 250 g were used in this study. Mandibular first molars were ligated with 3-0 silk suture. The rats received daily doses of 0.09% NaCl (control group) or 10 mg/kg body weight of CsA (test group) by intraperitoneal injections. Five rats from the control group and 10 rats from the test group were sacrificed at each experimental period (2, 4, 6, and 8 weeks after the beginning of CsA treatment). The specimens were examined immunohistochemically. Results: CD4(+), CD8(+), and CD45RO(+) T cells, and VEGF expression were more prevalent in the CsA-treated group than in the control group (P <0.05). VEGF was significantly correlated with CD4(+) T cells, CD4(+)/CD8(+) ratio, and CD45RO(+) cells (P<0.05). Conclusion: Based on our findings, we conclude that VEGF, a major regulator of angiogenesis, and CD4(+), CD8(+), and CD45RO(+) memory T cells play a key role in CsA-induced gingival overgrowth. J Periodontol 2012;83:248-255.en_US
dc.description.sponsorshipSelcuk University Scientific Research Project Service, Konya, TurkeySelcuk University [2004/014]en_US
dc.description.sponsorshipThis work is supported by the Selcuk University Scientific Research Project Service (BAP Project number 2004/014), Konya, Turkey. The authors thank Professor Said Bodur (Department of Public Health and Medical Statistics, Meram Faculty of Medicine, Selcuk University, Konya) for statistical analysis of the data. The authors report no conflicts of interest related to this study.en_US
dc.identifier.citationAlptekin, N. O., Ustun, K., Yaprak, E., Avunduk, M. C., Ataoglu, T., (2012). Immunohistochemical Analysis of CD45RO+ T Cells and Vascular Endothelial Growth Factor Expression in Cyclosporin A–Induced Rat Gingival Tissue. Journal of Periodontol. 83(2), 248-255. doi: 10.1902/jop.2011.110034.
dc.identifier.doi10.1902/jop.2011.110034en_US
dc.identifier.endpage255en_US
dc.identifier.issn0022-3492en_US
dc.identifier.issn1943-3670en_US
dc.identifier.issue2en_US
dc.identifier.pmid21692632en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage248en_US
dc.identifier.urihttps://dx.doi.org/10.1902/jop.2011.110034
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28126
dc.identifier.volume83en_US
dc.identifier.wosWOS:000300202800017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAlptekin, Nilgun Ozlem
dc.institutionauthorAtaoglu, Tamer
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCD4 antigenen_US
dc.subjectCD45RO antigenen_US
dc.subjectmodelsen_US
dc.subjectanimalen_US
dc.subjectvascular endothelial growth factor Aen_US
dc.titleImmunohistochemical Analysis of CD45RO(+) T Cells and Vascular Endothelial Growth Factor Expression in Cyclosporin A-Induced Rat Gingival Tissueen_US
dc.typeArticleen_US

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