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Öğe Calixarene Nanofiber Design for Human Colon Cancer 3D-Cell Culture(IEEE, 2017) Arpacı, P. Uyar; Özcan, Fatih; Ağaç, Müslüm; Ertul, ŞerefA growing body of evidence has suggested that 3D cell culture systems, in contrast to the 2D systems, represent more accurately the actual microenvironment where cells reside in tissues. Therefore, researchers have concentrated on developing realistic and sophisticated in-vitro 3D cell culture models that actually resemble the complex environment of native tissues. Calixarenes, similar to a ring basket, represent a third generation of supramolecular hosts could be promising candidates in this regard. Due to having a cyclic structure and large surface area, calixarenes, can be functionalized easily with polar and apolar groups, be a good carrier for cations, anions and neutral molecules. Electrospinning of p-tert-butylcalix[4] arene nanofibers with different functional groups were performed and their endothelial (Caco-2) and fibroblastic (L-929) cytocompatibility behaviour on cell adhesion function were examined. Cell attachment kinetics revealed that the (Caco-2) and L-929 attached to the nanofibers functionalized with pyridinumat position 3 at the same rate as to tissue culture plates. In this report, for the first time in literature, it was shown that 3D cultured systems designed with calixarene nanofibers provide excellent in vitro models, allowing the study of cellular responses in a setting that resembles in vivo environments.Öğe Electrospun Nanofibrous Polyacrylonitrile/calixarene Mats: an Excellent Adsorbent for the Removal of Chromate Ions from Aqueous Solutions(SLOVENSKO KEMIJSKO DRUSTVO, 2017) Bayrakcı, Mevlüt; Özcan, Fatih; Yılmaz, Bahar; Ertul, ŞerefHerein, calixarene molecules containing piperidine units at lower rim or upper rim of calix skeleton was turned into a water resistant composite nanofiber adsorbent using polyacrylonitrile (PAN) polymeric support via electrospinning process. The PAN based calixarene nanofibrous adsorbents showed an excellent adsorption capacity toward the toxic chromate anions in aqueous solution. Furthermore, this new nanofiber mats would be promising filter materials for drinking water purification.Öğe Fabrication of Calixarene Based Protein Scaffold by Electrospin Coating for Tissue Engineering(AMER SCIENTIFIC PUBLISHERS, 2018) Çağıl, Esra Maltaş; Özcan, Fatih; Ertul, ŞerefIn this study, calixarene was synthesized by using different functional groups as p-tert-butyl-Calix[4] arene ester and amides. Calixarene nanofibers were produced by electrospin coating. Protein immobilization onto the calixarene nanofibers was carried out with human serum albumin (HSA). The maximum amount of binding on produced three different calixarene nanofibers (DE, 2-AMP and 3-AMP) was compared by using a fluorescence technique for protein analysis. Result showed that maximum binding amount was found to be as 177.85 mg cm(-2) for 3-AMP surface. The protein binding was also characterized by using SEM, TEM, AFM and FT-IR. From obtained results, calixarene-albumin nanofiber was also fabricated by spin coating using 3-AMP which has ability max binding of protein.Öğe Improved Anticancer Efficacy of p-tert-butylcalix[4]arene through Surface Modifications(IEEE, 2017) Arpacı, Pembegül Uyar; Özcan, Fatih; Gök, Emine; Ertul, ŞerefThe search for new potent anticancer drugs that can only target cancer cells, rather than affecting normal tissues is very much commendable. Supramolecular Calixarene (p-tert-butylcalix[4]arene) is a highly promising candidate in this regard and could be modified to enhance preferential cytotoxicity for targeted therapy. Calixarenes are a family of bowl or cone shaped synthetic supramolecular macrocycles, composed of phenol units linked by methylene bridges through and an aldehyde. The proliferation rate of L-929 were observed higher than MCF-7 cells in the Real-Time Cell Analysis (RTCA) Systems. Our research directs that calixarene shows effective preferential cytotoxicity at a concentration range of 25 to 100 mu g/mL with enhanced preferential cytotoxicity shown by the modification of pyridinium group at the position 3 against MCF-7 breast cancer cells. In this present study, the effect of surface altered calixarene by pyridinium groups on preferential cytotoxicity in cancer cell in-vitro by comparing with innate preferential toxicity shown by unaltered. The results reported in this study demonstrated that tumor-preferential in-vitro cytotoxicity of p-tert-butylcalix[4] arene against MCF-7 over L-929 cells present a promising approach for efficient and safe cancer therapy.Öğe Phase Solubility Studies of Poorly Soluble Drug Molecules by Using O-Phosphorylated Calixarenes as Drug-Solubilizing Agents(AMER CHEMICAL SOC, 2012) Bayrakçı, Mevlüt; Ertul, Şeref; Yılmaz, MustafaThis study is the first report on the solubilizing effect of O-phosphorylated calix[n]arenes that form complexes with neutral molecules such as nifedipine, niclosamide, and furosemide by host-guest complexation. These complexation studies were carried out by using the phase solubility technique. From the obtained results, it was observed that the solubility of guest molecules such as nifedipine, niclosamide, and furosemide was significantly increased in the presence of host molecules tetrakis-O-(diethoxyphosphoryl)-p-tert-butylcalix[4]arene (1), tetrakis-O-(diethoxyphosphoryl)-calix[4]arene (2), bis-O-(diethoxyphosphoryl)-p-tert-butylcalix[4]arene (3), bis-O-(diethoxyphosphoryl)-calix[4]arene (4), and octakis-O-(diethoxyphosphoryl)-p-tert-butylcalix[8]arene (5). The increase in solubility of drugs by the calixarene host 1 to 5 was most probably due to inclusion complexation between drug molecules and cavities of the calixarene skeleton similar to drug-cyclodextrin complexes.Öğe Solubilizing Effect of the P-Phosphonate Calix[n]arenes Towards Poorly Soluble Drug Molecules Such as Nifedipine, Niclosamide and Furosemide(SPRINGER, 2012) Bayrakçı, Mevlüt; Ertul, Şeref; Yılmaz, MustafaThis article reports the solubilization of the practically water insoluble drug molecules such as nifedipine, niclosamide and furosemide by guest:host inclusion complexation with p-phosphonates calix[n]arenes as drug soluble agent. This complexation studies were carried out by using the phase solubility technique. From the obtained results, it was observed that the solubility of drug molecules was significantly increased in the presence of calix[n]arene host molecules. The increase in solubility of drugs by the calix[n]arene was most probably due to inclusion complexation between drug molecules and cavities of the calixarene skeleton similar to drug:cyclodextrin complexes.Öğe Synthesis and characterization of novel nanofiber based calixarene and its binding efficiency towards chromium and uranium ions(SPRINGER, 2016) Özcan, Fatih; Bayrakcı, Mevlüt; Ertul, ŞerefThe objective of this study is to obtain nanofibrous precursor based calixarene with high ion adsorption capacity by electrospinning of blended solution of polyacrylonitrile (PAN) and upper rim functionalized calix[4]arene bearing N-methylglucamine (Calix-NMG). The obtained electrospun fibers were characterized using fourier transform infrared (FT-IR-ATR), scanning electron microscope (SEM) equipped with energy-dispersive X-ray spectrometry (EDX) and thermogravimetric analyses (TGA and DSC). Analysis indicated that preparation of nanofibers based Calix-NMG was successfully achieved. The ion binding studies exhibited that the nanofiber based Calix-NMG could be efficiently used for the binding of chromate anions and uranium cations. Nanofiber based calix[4]arene with N-methylglucamine chelating groups may be a good candidate as a filter material for treatment of a large quantity of wastewater owing to their very large surface area as well as both the inclusion and donor-acceptor complexation capability of all surfaces associated with the calixarene skeleton.Öğe Synthesis and Complex-Formation of Substituted Aminoglyoximes of Unsymmetrical Vic-Dioximes(TAYLOR & FRANCIS INC, 1994) Sevindir, Cahit H.; Mirzaoğlu, Ramazan; Özcan, Emine; Ertul, Şeref; Güler, ErsinThree new substituted aminoglyoximes, p-chloroanilinoglyoxime (p-CAGH2), o-chloroanilinoglyoxime (o-CAGH2), M-chloroanilinoglyoxime (M-CAGH2) have been synthesized from anti-chloroglyoxime (CPGH2) and the corresponding substituted amines. The Ni(II) and Cu(II) complexes of these ligands are square-planer while the Co(II) complexes are octahedral with water molecules as axial ligands. H-1-NMR, mass, IR spectra and elemental analyses data of the new compounds are given.Öğe Synthesis and Extraction Study of Calix[4]Arene Dinitrile Derivatives Incorporated in a Polymeric Backbone with Bisphenol-A(KLUWER ACADEMIC/PLENUM PUBL, 2001) Memon, Shahabuddin; Oğuz, Oğuz; Yılmaz, Aydan; Tabakçı, Mustafa; Yılmaz, Mustafa; Ertul, ŞerefTwo new copolymers containing pendant calix[4]arene units with nitrile functionalities at their lower rim have been synthesized via nucleophilic substitution reactions involving 5,11,17,23-tetra-tert-butyl-25,27-bis(cyanomethoxy)-26,28-dihydroxy-calix[4]arene (3) or 25,27-bis(cyanometh oxy)-26,28-dihydroxy-calix[4]arene (4) with 1,5-dibromopentane and bisphenol-A. The phase transfer studies were performed by using liquid-liquid extraction procedures. It has been deduced from the observations that both copolymers show a good phase transfer affinity toward selected alkali, alkaline earth, and transition metal cations, unlike their precursor (3).Öğe Synthesis of Novel Lactam Ionophores Containing Crown Ether Moieties and Investigation of Their Extraction Abilities Towards Heavy Metal Cations(SPRINGER, 2010) Ertul, ŞerefThe article describes the syntheses and extraction properties of new lactam ionophores. These lactam derivatives were easily synthesized via aminolysis of dimethyl 2,2'-(6,6'-methylenebis(2-tert-butyl-4-methyl-6,1-phenylene)bis(oxy))diacetate or dimethyl 2,2'-(2,2'-methylenebis(4-chloro-2,1-phenylene))bis(oxy)diacetate with corresponding diamine compounds at one step. The extraction studies of lactam ionophores were performed toward dichromate anion and alkaline and transition metals such as Li+, Na+, K+, Co2+, Hg2+ and Pb2+. All the structures of the ionophores were confirmed by spectroscopic techniques and elemental analysis.Öğe The Synthesis of Three New Macrocyclic Ligands and Preparation of Some of Their Cationic Complexes(MARCEL DEKKER INC, 1993) Sezgin, Mehmet; Bedük Dinçer, A.; Ertul, Şeref; Koçak, AhmetIn this study the synthesis of macrocyclic ligands 15,21-dinitro-2,5,8,11-tetraoxatricyclo(17,4,0,0(12,17)) tricosa-1 (23),12,14,16,19,21-hexaene-3,10-dione (I); 18,24-dinitro-2,5,8,11,14-pentaoxatricyclo(20,4,0,0(15,20)) hexacosa-1(26),15, 17,19,22,24-hexaene-3,13-dione (II) and 15,21-di-t-butyl-2,5,8,11-tetraoxatricyclo(17,4,0,0(12,17)) tricosa-1(23),12,14,16, 19,21-hexaene-3,10-dione (III) are described. Attemption of the preparation of their complexes in crystalline form with NaClO4.H2O, KClO4, and Ba(ClO4)2 . 3H2O are discussed.Öğe Taç Eter İhtiva Eden İki Makrosiklik Lakton'un Sentezi Metal Komplekslerinin Hazırlanması ve Ekstraksiyon Çalışmaları(Selçuk Üniversitesi Fen-Edebiyat Fakültesi, 2007) Bedük, Ahmet Dinçer; Ertul, Şeref; Koçak, Ahmet; Sezgin, Mehmet; Bayrakçı, MevlütBu çalışmada oksijen ihtiva eden makrosiklik ligandlar 2,3,5,6-Bis[373")-t-but545) metilbenzo)-8,15-diketo-15C4 (Lu). 2,3,5,6-Bis[3(35)-t-batil-545')metilbenzo) 8,18-diketo-1805 (La) sentezlenmiş ve oluşan ligandlarin alkali ve gecis metallerle olan kompleksleşme yetenekleri incelenmiştir. Sentezlenen bileşiklerin yapıları 'H. NMR, IR, Elemental analiz yöntemleri ile aydınlatılmaya çalışılmiştir. Ayrıca oluşan ligandlann metal-pikrat ekstrasiyon çalışmaları yapılmıştır.Öğe Taç Eter ihtiva Eden Makrosiklik Ligandların Sentezi ve Ekstraksiyon Çalışmaları(Selçuk Üniversitesi Fen-Edebiyat Fakültesi, 2007) Koçak, Ahmet; Sezgin, Mehmet; Ertul, Şeref; Bedük, Ahmet Dinçer; Malkondu, SaitBu çalışmada oksijen ihtiva eden makrosiklik ligandlar 2,3,5,6-Bis[3'-bromo3,5-di-tert-butil benzo-5 fenil benzo]12C3 (L1), 2,3,5,6-Bis[3'-bromo-3,5-di-tert-butil benzo-5 fenil benzo)15C4 (L2) 2,3,5,6-Bis[3-bromo-3,5-di-tert-butil benzo-5 fenil benzo)-8,12 diketo 1203 (L3). 2,3,5,6-Bis[3-bromo-3,5-di-tert-butil benzo-5 fenil 1-8 18 diketo 18C5 (L) sentezleri gerçekleştirilm ve geçiş metallerle olan metal-pikrat ekstraksiyon çalışmaları denenmiştir. Sentezlenen bileşiklerin yapıları 'H-NMR, IR, Elemental analiz yöntemleri ile aydınlatılmaya çalışılmıştır.Öğe The Use of Calixarene Nanofibers as an HPLC Column Filler(IEEE, 2017) Ali, S. S.; Şen, Nejdet; Durmaz, Fatih; Özcan, Fatih; Ertul, ŞerefThe third generation molecule of supramolecule chemistry, the calixarenes, is superior to the first and second generation molecules, Tac Ethers and Cyclodextrins, due to their ability to be obtained in greater quantities in higher purity and easier to function. The fact that the calixarenne compounds are important in the host-guest chemistry, and that they are ring structures, can carry molecules, anions or cations with advantages such as the absence of molecules [1-3]. In this work, the p-tert-butylcalix[4] arene diester compound was reacted with benzylamine. The structure of the p-tert-butylcalix[4] arene benzylamide molecule obtained as a result of the reaction was elucidated by H-1-NMR and then electrospun nanofibers were used as an HPLC column filler.
