Pre and Postprandial Total Serum Bile Acid Concentration Following Acute Liver Damage in Dogs
Yükleniyor...
Dosyalar
Tarih
1997
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
BLACKWELL WISSENSCHAFTS-VERLAG GMBH
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The importance of preprandial and postprandial total bile acids were investigated in dogs with liver damage induced by carbon tetrachloride (CCl4) administration. Six healthy and mature dogs were used. After base-line clinical and biochemical examinations, hepatocellular damage was induced by oral CCl4 administration. Determinations of plasma total protein (TP), albumin (Alb), total and direct bilirubin (TBil, DBil), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) along with histologic ex-amination of the livers 10 days following CCl4 administration were conducted to ensure that hepatic damage was in fact induced by the CCl4 administration. Twelve h fasting preprandial and 2 h postprandial serum total bile acids (PRSBA, POSBA) concentrations were also measured. The median plasma TP, Alb, TBil and DBil concentrations did nor show any difference (P > 0.05) during the study. Plasma ALT activities increased significantly (P < 0.05, P < 0.01) between on the 3rd and 10th days of the experiment. The median serum values of PRSBA and POSBA were significantly different (P < 0.01) on the first day and continued to be different during the experiment. In conclusion, POSBA seemed to be more reliable than PRSBA in the diagnosis of hepatic necrosis.
Açıklama
Anahtar Kelimeler
Kaynak
Journal of Veterinary Medicine Series a-physiology Pathology Clinical Medicine
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
44
Sayı
1
Künye
Turgut, K., Demir, C., Ok, M., Çiftçi, K., (1997). Pre and Postprandial Total Serum Bile Acid Concentration Following Acute Liver Damage in Dogs. Journal of Veterinary Medicine Series a-Physiology Pathology Clinical Medicine, 44(1), 25-29.
