Histologic Characteristics and Local Cellular Immunity of the Gland of the Third Eyelid After Topical Ophthalmic Administration of 2% Cyclosporine for Treatment of Dogs With Keratoconjunctivitis Sicca

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dc.contributor.authorİzci, Celal
dc.contributor.authorÇelik, İlhami
dc.contributor.authorAlkan, Fahrettin
dc.contributor.authorOğurtan, Zeki
dc.contributor.authorCeylan, Cengiz
dc.contributor.authorSur, Emrah
dc.contributor.authorÖzkan, Yasemin
dc.date.accessioned2020-03-26T16:39:10Z
dc.date.available2020-03-26T16:39:10Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective-To evaluate the efficacy of topical administration of a 2% solution of cyclosporine (CsA) for treatment of dogs with keratoconjunctivitis sicca (KCS) and to correlate results with histopathologic characteristics and local cellular immunity of the gland of the third eyelid. Animals-24 dogs with bilateral KCS. Procedure-Lacrimal secretion was measured, using Schirmer tear test (STT) strips. Leukocyte and T-lymphocyte subsets were determined in blood samples. Histopathologic changes as well as CD4+, CD8+, and alpha-naphthyl-acetate esterase-positive (ANAE+) lymphocytes were evaluated. Results-Clinical signs resolved at the end of 1 month in conjunction with significantly increased STT values, compared with baseline values. Fifteen and 30 days after discontinuation of CsA treatment, a decrease was observed in STT values in both eyes; however, only values for the right eye were significantly different. There was a significant decrease in the number of lymphocytes and ANAE+ lymphocytes 15 and 30 days after discontinuation of CsA treatment, compared with baseline values. Differences were not observed in number of CD4+ lymphocytes among treatment groups. However, there was a significant decrease in number of CD8+ lymphocytes with reversal of the CD4+:CD8+ in both eyes after CsA treatment for 30 days, compared with the control group. Increased secretory activity and decreased lymphocyte infiltration were characteristic histopathologic findings. Conclusions and Clinical Relevance-Topical administration of a 2% solution of CsA was effective for the treatment of dogs with KCS. Strict follow-up monitoring is required after the cessation of treatment because of the possibility of recurrence of KCS.en_US
dc.identifier.citationİzci, C., Çelik, İ., Alkan, F., Oğurtan, Z., Ceylan, C., Sur, E., Özkan, Y., (2002). Histologic Characteristics and Local Cellular Immunity of the Gland of the Third Eyelid After Topical Ophthalmic Administration of 2% Cyclosporine for Treatment of Dogs With Keratoconjunctivitis Sicca. American Journal of Veterinary Research, 63(5), 688-694. Doi: 10.2460/ajvr.2002.63.688
dc.identifier.doi10.2460/ajvr.2002.63.688en_US
dc.identifier.endpage694en_US
dc.identifier.issn0002-9645en_US
dc.identifier.issue5en_US
dc.identifier.pmid12013470en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage688en_US
dc.identifier.urihttps://dx.doi.org/10.2460/ajvr.2002.63.688
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17971
dc.identifier.volume63en_US
dc.identifier.wosWOS:000175361800012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorİzci, Celal
dc.institutionauthorÇelik, İlhami
dc.institutionauthorAlkan, Fahrettin
dc.institutionauthorOğurtan, Zeki
dc.institutionauthorCeylan, Cengiz
dc.institutionauthorSur, Emrah
dc.institutionauthorÖzkan, Yasemin
dc.language.isoenen_US
dc.publisherAmer Veterinary Medical Assocen_US
dc.relation.ispartofAmerican Journal of Veterinary Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleHistologic Characteristics and Local Cellular Immunity of the Gland of the Third Eyelid After Topical Ophthalmic Administration of 2% Cyclosporine for Treatment of Dogs With Keratoconjunctivitis Siccaen_US
dc.typeArticleen_US

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