Transfer and integration of breast milk stem cells to the brain of suckling pups
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
NATURE PUBLISHING GROUP
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Beside its unique nutritional content breast milk also contains live cells from the mother. Fate of these cells in the offspring has not been adequately described. In this study, we aimed to detect and identify maternal cells in the suckling's blood and the brain. Green fluorescent protein expressing transgenic female mice (GFP+) were used as foster mothers to breastfeed wildtype newborn pups. One week and two months after the birth, blood samples and brains of the sucklings were analyzed to detect presence of GFP+ cells by fluorescence activated cell sorting, polymerase chain reaction and immunohistochemistry on the brain sections and optically cleared brains. The tests confirmed that maternal cells were detectable in the blood and the brain of the pups and that they differentiated into both neuronal and glial cell types in the brain. This phenomenon represents breastfeeding - induced microchimerism in the brain with functional implications remain to be understood.
Açıklama
Anahtar Kelimeler
Kaynak
SCIENTIFIC REPORTS
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
8
Sayı
Künye
Aydın, M. Ş., Yiğit, E. N., Vatandaşlar, E., Erdoğan, E., Öztürk, G. (2018). Transfer and Integration of Breast Milk Stem Cells to the Brain of Suckling Pups. Scientific Reports, 8.
