Transfer and integration of breast milk stem cells to the brain of suckling pups

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dc.contributor.authorAydin, Mehmet Serif.
dc.contributor.authorYigit, Esra Nur.
dc.contributor.authorVatandaslar, Emre.
dc.contributor.authorErdogan, Ender.
dc.contributor.authorOzturk, Gurkan.
dc.date.accessioned2020-03-26T20:11:37Z
dc.date.available2020-03-26T20:11:37Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBeside its unique nutritional content breast milk also contains live cells from the mother. Fate of these cells in the offspring has not been adequately described. In this study, we aimed to detect and identify maternal cells in the suckling's blood and the brain. Green fluorescent protein expressing transgenic female mice (GFP+) were used as foster mothers to breastfeed wildtype newborn pups. One week and two months after the birth, blood samples and brains of the sucklings were analyzed to detect presence of GFP+ cells by fluorescence activated cell sorting, polymerase chain reaction and immunohistochemistry on the brain sections and optically cleared brains. The tests confirmed that maternal cells were detectable in the blood and the brain of the pups and that they differentiated into both neuronal and glial cell types in the brain. This phenomenon represents breastfeeding - induced microchimerism in the brain with functional implications remain to be understood.en_US
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114R078]en_US
dc.description.sponsorshipThis project was supported by "The Scientific and Technological Research Council of Turkey" (TUBITAK) with a grant number 114R078.en_US
dc.identifier.citationAydın, M. Ş., Yiğit, E. N., Vatandaşlar, E., Erdoğan, E., Öztürk, G. (2018). Transfer and Integration of Breast Milk Stem Cells to the Brain of Suckling Pups. Scientific Reports, 8.
dc.identifier.doi10.1038/s41598-018-32715-5en_US
dc.identifier.issn2045-2322en_US
dc.identifier.pmid30250150en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1038/s41598-018-32715-5
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37095
dc.identifier.volume8en_US
dc.identifier.wosWOS:000445336600057en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErdogan, Ender.
dc.language.isoenen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.relation.ispartofSCIENTIFIC REPORTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleTransfer and integration of breast milk stem cells to the brain of suckling pupsen_US
dc.typeArticleen_US

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