Determination of melatonin deprivation impact on sepsis with acute phase reactants

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dc.contributor.authorAkbulut, Hatice Feyza
dc.contributor.authorVatansev, Hüsamettin
dc.contributor.authorSekmenli, Tamer
dc.date.accessioned2020-03-26T20:20:12Z
dc.date.available2020-03-26T20:20:12Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Çumra Meslek Yüksekokulu, Bitkisel ve Hayvansal Üretim Bölümüen_US
dc.description.abstractBackground: The aim of the present study is to determine the association of melatonin hormone level on CRP, Total Antioxidant Status, Leukocyte, Procalcitonin, and Malondialdehyde, all acute phase reactants in the dark and light cycle of rats with sepsis model. Materials and methods: In this study, 54 rats were divided into three groups. Whereas the first and third groups had a 12 h dark-light cycle, the second group was exposed to light for 24 h at 21 degrees C-22 degrees C for 10 d without any water and food restrictions. In the second and third groups, sepsis model was formed by cecal ligation and puncture (CLP) method at the end of 10th day, and blood samples were taken at the end of the 10th day. C-reactive protein, Malondialdehyde, Procalcitonin in the blood samples were analyzed by ELISA, and the levels of Total Antioxidant Status and leukocyte were determined by colorimetric method in the subsequent 12 and 24 h. Results: CRP values increased in the second group rats, which were kept continuously under light and had undergone CLP, from 288.8 mg/L to 584.0 mg/L at the end of the 12 h and the end of the 24 h, approximately, two times. In rats, which were kept under 12 h of light, 12 h of darkness, and applied CLP (group 3), these values increased from 416.9 to 619.1; an increase of 1.5 times. When assessed for MDA, it was determined that the differences between Group 2 and Group 3 were more prominent between 0 h and 12 h. While the MDA values in group 2 increased from 16.53 nmol/mL at the 12 h to 17.66 nmol/mL at the 24 h. However, MDA values did not yield statistically significant changes in the third group. Changes in the in PCT values were similar to the MDA values obtained. Increase coefficient of the PCT values between 0 h and 12 h in the second group 2 was 1.26; however, in the third group, it was negligible. Conclusions: An increase in the oxidative stress was observed in the rats that underwent CLP and melatonin deprivation via continuous 24 h light exposure for 10 d. Accordingly, deprivation of light is considered to be effective in sepsis treatment due to the increase in melatonin levels in intensive care unit patients. (C) 2019 Elsevier Inc. All rights reserved.en_US
dc.identifier.citationAkbulut, H. F., Vatansev, H., Sekmenli, T. (2020). Determination of Melatonin Deprivation Impact on Sepsis with Acute Phase Reactants. Journal of Surgical Research, 247, 108-114.
dc.identifier.doi10.1016/j.jss.2019.10.036en_US
dc.identifier.endpage114en_US
dc.identifier.issn0022-4804en_US
dc.identifier.issn1095-8673en_US
dc.identifier.pmid31806239en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage108en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jss.2019.10.036
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38530
dc.identifier.volume247en_US
dc.identifier.wosWOS:000513908200014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAkbulut, Hatice Feyza.
dc.institutionauthorVatansev, Hüsamettin.
dc.institutionauthorSekmenli, Tamer.
dc.language.isoenen_US
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen_US
dc.relation.ispartofJOURNAL OF SURGICAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSepsisen_US
dc.subjectMelatoninen_US
dc.subjectC-reactive proteinen_US
dc.subjectMalondialdehydeen_US
dc.subjectTotal antioxidant statusen_US
dc.subjectWhite blood cellen_US
dc.subjectProcalcitoninen_US
dc.titleDetermination of melatonin deprivation impact on sepsis with acute phase reactantsen_US
dc.typeArticleen_US

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