Assessment of potential cardiovascular risk in trichloroethylene exposure by serum methylated arginine levels

Basit Öğe Kaydı
dc.authorid0000-0001-6140-8331
dc.contributor.authorIritas, Servet Birgin.
dc.contributor.authorDip, Aybike.
dc.contributor.authorGunduzoz, Meside.
dc.contributor.authorTutkun, Lutfiye.
dc.contributor.authorTurksoy, Vugar Ali.
dc.contributor.authorDeniz, Serdar.
dc.contributor.authorTekin, Gulsum.
dc.contributor.authorOztan, Ozgur.
dc.contributor.authorUnlu, Ali.
dc.date.accessioned2020-03-26T20:12:37Z
dc.date.available2020-03-26T20:12:37Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümüen_US
dc.description.abstractTrichloroethylene (TCE) is a widely used solvent in industrial applications and has toxic effects on various systems. Methylated arginine amino acids (eg asymmetric dimethyl arginine (ADMA), symmetric dimethyl arginine (SDMA)) cause the development of cardiovascular disease by inhibiting NO synthesis, which is considered to be heart-protector. The aim of this study is to determine the risk of cardiovascular diseases in TCE exposure by methylated arginine biomarkers. About 98 controls and 100 TCE-exposed male subjects were included in the study. Trichloroacetic acid (urinary metabolite of TCE), arginine, homoarginine, citrulline ADMA, SDMA, and N-monomethyl L-arginine (L-NMMA) levels were found significantly higher than control group (p < 0.001). The strongest correlation was found between ADMA and Trichloroacetic acid (TCA) level (r = 0.453, p < 0.01). Long-term TCE exposure, may be an important risk factor for cardiovascular diseases by increasing methylated arginine levels.en_US
dc.identifier.citationIritas, S. B., Dip, A., Gunduzoz, M., Tutkun, L., Turksoy, V. A., Deniz, S., Tekin, G., Oztan, O., Unlu, A. (2019). Assessment of Potential Cardiovascular Risk in Trichloroethylene Exposure by Serum Methylated Arginine Levels. International Journal of Environmental Health Research, 31(1), 63-74.
dc.identifier.doi10.1080/09603123.2019.1628927en_US
dc.identifier.endpage74
dc.identifier.issn0960-3123en_US
dc.identifier.issn1369-1619en_US
dc.identifier.issue1
dc.identifier.pmid31232082en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage63
dc.identifier.urihttps://dx.doi.org/10.1080/09603123.2019.1628927
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37506
dc.identifier.volume31
dc.identifier.wosWOS:000475135400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTekin, Gulsum.
dc.institutionauthorUnlu, Ali.
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAsymmetric dimethylarginine (ADMA)en_US
dc.subjectsymmetric dimethylarginine (SDMA)en_US
dc.subjectarginineen_US
dc.subjecttrichloroethylene (TCE) toxicityen_US
dc.subjectcardiovascular risken_US
dc.titleAssessment of potential cardiovascular risk in trichloroethylene exposure by serum methylated arginine levelsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Servet Birgin Iritas.pdf
Boyut:
1.57 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Full Text Access
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Sağlık Hizmetleri Meslek Yüksekokulu Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıbbi Biyokimya/Makale Koleksiyonu