Association of depressive symptoms with 25(OH) vitamin D in hemodialysis patients and effect of gender

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dc.contributor.authorYavuz, Yasemin Coşkun
dc.contributor.authorBıyık, Zeynep
dc.contributor.authorÖzkul, Durmuş
dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorEryavuz, Duygu
dc.contributor.authorDağ, Mikail
dc.contributor.authorKörez, Muslu Kazım
dc.contributor.authorGüney, İbrahim
dc.contributor.authorAltıntepe, Lütfullah
dc.date.accessioned2020-03-26T20:20:08Z
dc.date.available2020-03-26T20:20:08Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground Depression is common in chronic kidney disease ( CKD) patients and associated with significant increase in morbidity and mortality. In recent years, a relationship between vitamin D deficiency and depression has been shown. The aim of this study is to investigate the relationship between 25-hydroxy (OH) vitamin D and depression in hemodialysis patients. Methods A total of 140 patients were included in the study. Hamilton depression scale (HAM-D) was completed by all patients. 25(OH) vitamin D levels were compared between patients with and without depressive symptoms. Results Patients who had depressive symptoms had significantly lower 25(OH) vitamin D levels (13.70 [24.3-8.25] vs. 18.20 [29.2-11.7] ng/mL, p = 0.016). HAM-D score showed significant association with gender (p = 0.011) and 25(OH) vitamin D level (p = 0.011). Univariate logistic regression analysis showed that males had lower risk of depression by a ratio of 61.1% (OR 0.389, p = 0.012) and vitamin D-deficient patients had 2.88 times greater risk of depression compared to non-deficient patients (OR 2.885, p = 0.013). Multivariate logistic regression analysis showed that males had 53.7% less risk of depression (OR 0.463, p = 0.046) and vitamin D-deficient patients had 2.39 times greater risk of depression (OR 2.397, p = 0.047). When evaluated by gender, univariate logistic regression analysis showed that 25(OH) vitamin D and other variables were not associated with depression in females (p > 0.05), while only vitamin D level had a significant effect on depression in males (OR 8.207, p = 0.008). Conclusions We found a significant association between vitamin D level and depressive symptoms in hemodialysis patients. When analyzed according to gender, this association was found to stand independent of other variables only in males.en_US
dc.identifier.citationYavuz, Y. C., Biyik, Z., Ozkul, D., Abusoglu, S., Eryavuz, D., Dag, M., Korez, M. K., Guney, I., Altintepe, L. (2020). Association of Depressive Symptoms with 25(OH) Vitamin D in Hemodialysis Patients and Effect of Gender. Clinical and Experimental Nephrology, 24(1), 63-72.
dc.identifier.doi10.1007/s10157-019-01794-7en_US
dc.identifier.endpage72en_US
dc.identifier.issn1342-1751en_US
dc.identifier.issn1437-7799en_US
dc.identifier.issue1en_US
dc.identifier.pmid31544220en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage63en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10157-019-01794-7
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38511
dc.identifier.volume24en_US
dc.identifier.wosWOS:000510932200004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYavuz, Yasemin Coşkun
dc.institutionauthorBıyık, Zeynep.
dc.institutionauthorAbuşoğlu, Sedat
dc.institutionauthorEryavuz, Duygu
dc.institutionauthorDağ, Mikail
dc.institutionauthorKörez, Muslu Kazım
dc.institutionauthorAltıntepe, Lütfullah
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofCLINICAL AND EXPERIMENTAL NEPHROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDepressionen_US
dc.subjectGenderen_US
dc.subjectHemodialysisen_US
dc.subjectVitamin Den_US
dc.titleAssociation of depressive symptoms with 25(OH) vitamin D in hemodialysis patients and effect of genderen_US
dc.typeArticleen_US

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