Investigation of Ecotoxic Effect of 2,4-Dichlorophenoxyacetic Acid Dimethylamine on Liver and Pancreas
Yükleniyor...
Dosyalar
Tarih
2012
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Asian Journal of Chemistry
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, ecotoxic effects of 2,4-dichlorophenoxyacetic acid dimethylamine salt herbicide were investigated on the liver and pancreas of rats. Azaserine-rat model developed by Longnecker and Curphey was used in this research. As a result of this study, hydropic degenerations in parenchyma which were on the point of being more distinct in localized hepatocytes especially in the vena centralis periphery of the liver, dilatation in sinusoids and kupffer cell proliferation were observed. It was found that 200 mg/kg/day dose of 2,4-dichlorophenoxyacetic acid dimethylamine salt caused the formation of neoplastic variations in the pancreas and liver of rats. It was also indicated that the development of neoplastic variations which were experimentally formed by using azaserine was increased (diameter of focus, volume of focus). These results indicate the possibility of these herbicides to be cancer initiator during long exposures.
Açıklama
Anahtar Kelimeler
2,4-Dichlorophenoxyacetic acid dimethylamine salt, Herbicide, Atypical cell focuses, Pancreas, Liver, Ecotoxic effect, Quantitative analysis
Kaynak
Asian Journal of Chemistry
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
24
Sayı
4
Künye
Kalıpcı, E., Özdemir, C., (2012). Investigation of Ecotoxic Effect of 2,4-Dichlorophenoxyacetic Acid Dimethylamine on Liver and Pancreas. Asian Journal of Chemistry, 24(4), 1559-1562.
