Investigation of Ecotoxic Effect of 2,4-Dichlorophenoxyacetic Acid Dimethylamine on Liver and Pancreas

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dc.contributor.authorKalıpcı, Erkan
dc.contributor.authorÖzdemir, Celalettin
dc.date.accessioned2020-03-26T18:30:45Z
dc.date.available2020-03-26T18:30:45Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, ecotoxic effects of 2,4-dichlorophenoxyacetic acid dimethylamine salt herbicide were investigated on the liver and pancreas of rats. Azaserine-rat model developed by Longnecker and Curphey was used in this research. As a result of this study, hydropic degenerations in parenchyma which were on the point of being more distinct in localized hepatocytes especially in the vena centralis periphery of the liver, dilatation in sinusoids and kupffer cell proliferation were observed. It was found that 200 mg/kg/day dose of 2,4-dichlorophenoxyacetic acid dimethylamine salt caused the formation of neoplastic variations in the pancreas and liver of rats. It was also indicated that the development of neoplastic variations which were experimentally formed by using azaserine was increased (diameter of focus, volume of focus). These results indicate the possibility of these herbicides to be cancer initiator during long exposures.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk University [09101055]en_US
dc.description.sponsorshipThe authors gratefully acknowledged the Selcuk University Research Fund (BAP) for its financial support (Project No. 09101055).en_US
dc.identifier.citationKalıpcı, E., Özdemir, C., (2012). Investigation of Ecotoxic Effect of 2,4-Dichlorophenoxyacetic Acid Dimethylamine on Liver and Pancreas. Asian Journal of Chemistry, 24(4), 1559-1562.
dc.identifier.endpage1562en_US
dc.identifier.issn0970-7077en_US
dc.identifier.issn0975-427Xen_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1559en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28160
dc.identifier.volume24en_US
dc.identifier.wosWOS:000300464200035en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKalıpcı, Erkan
dc.institutionauthorÖzdemir, Celalettin
dc.language.isoenen_US
dc.publisherAsian Journal of Chemistryen_US
dc.relation.ispartofAsian Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subject2,4-Dichlorophenoxyacetic acid dimethylamine salten_US
dc.subjectHerbicideen_US
dc.subjectAtypical cell focusesen_US
dc.subjectPancreasen_US
dc.subjectLiveren_US
dc.subjectEcotoxic effecten_US
dc.subjectQuantitative analysisen_US
dc.titleInvestigation of Ecotoxic Effect of 2,4-Dichlorophenoxyacetic Acid Dimethylamine on Liver and Pancreasen_US
dc.typeArticleen_US

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