Short-Term, High-Dose Corticosteroid-Therapy in Childhood Acute Immune Thrombocytopenic Purpura
Yükleniyor...
Dosyalar
Tarih
1995
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mosby-Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We read with interest the article by Blanchette et al. 1 A therapeutic regimen that increases the platelet count above a safe level for preventing intracranial hemorrhage by use of orally administered corticosteroids in relatively low doses would be the preferred form of therapy, but we think that the continuation of this therapy for 3 weeks is disadvantageous because of the development of untoward effects and the prolongation of therapy. Side effects may occur with the continued daily use of corticosteroids, and the hy pothalamus-pituitary-adrenal system would be suppressed if steroids were administered for periods longer than 15 days. 2 Moreover, effective treatment without any side effects have been reported in studies in which methylprednisolone was used in very high doses orally for 1 week. 3 We are still investigating'the effect of orally administered methylprednisolone, 10 mg/kg per day, for 5 days in the treatment of acute immune thrombocytopenic purpura in children. The preliminary data for 10 patients revealed mild elevation of the blood glucose concentration in two patients on day 3 and in the occult blood in the stool in one patient on day 7, which were transient. The mean platelet count increased from 21 X 109/L, to 47 × 109/L on the third day of therapy. The platelet count decreased below 20 x 109/L in only one patient during follow-up.
Açıklama
Anahtar Kelimeler
Kaynak
Journal of Pediatrics
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
126
Sayı
1
Künye
Yavuz, H., Özel, A., Erkul, İ., (1995). Short-Term, High-Dose Corticosteroid-Therapy in Childhood Acute Immune Thrombocytopenic Purpura. Journal of Pediatrics, 126(1), 156-156.
