Short-Term, High-Dose Corticosteroid-Therapy in Childhood Acute Immune Thrombocytopenic Purpura

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dc.contributor.authorYavuz, Haluk
dc.contributor.authorÖzel, Ahmet
dc.contributor.authorErkul, İbrahim
dc.date.accessioned2020-03-26T16:24:33Z
dc.date.available2020-03-26T16:24:33Z
dc.date.issued1995
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe read with interest the article by Blanchette et al. 1 A therapeutic regimen that increases the platelet count above a safe level for preventing intracranial hemorrhage by use of orally administered corticosteroids in relatively low doses would be the preferred form of therapy, but we think that the continuation of this therapy for 3 weeks is disadvantageous because of the development of untoward effects and the prolongation of therapy. Side effects may occur with the continued daily use of corticosteroids, and the hy pothalamus-pituitary-adrenal system would be suppressed if steroids were administered for periods longer than 15 days. 2 Moreover, effective treatment without any side effects have been reported in studies in which methylprednisolone was used in very high doses orally for 1 week. 3 We are still investigating'the effect of orally administered methylprednisolone, 10 mg/kg per day, for 5 days in the treatment of acute immune thrombocytopenic purpura in children. The preliminary data for 10 patients revealed mild elevation of the blood glucose concentration in two patients on day 3 and in the occult blood in the stool in one patient on day 7, which were transient. The mean platelet count increased from 21 X 109/L, to 47 × 109/L on the third day of therapy. The platelet count decreased below 20 x 109/L in only one patient during follow-up.en_US
dc.identifier.citationYavuz, H., Özel, A., Erkul, İ., (1995). Short-Term, High-Dose Corticosteroid-Therapy in Childhood Acute Immune Thrombocytopenic Purpura. Journal of Pediatrics, 126(1), 156-156.
dc.identifier.doi10.1016/S0022-3476(95)70530-9en_US
dc.identifier.endpage156en_US
dc.identifier.issn0022-3476en_US
dc.identifier.issn1097-6833en_US
dc.identifier.issue1en_US
dc.identifier.pmid7815211en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage156en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S0022-3476(95)70530-9
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16298
dc.identifier.volume126en_US
dc.identifier.wosWOS:A1995QB18400034en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYavuz, Haluk
dc.institutionauthorÖzel, Ahmet
dc.institutionauthorErkul, İbrahim
dc.language.isoenen_US
dc.publisherMosby-Elsevieren_US
dc.relation.ispartofJournal of Pediatricsen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleShort-Term, High-Dose Corticosteroid-Therapy in Childhood Acute Immune Thrombocytopenic Purpuraen_US
dc.typeLetteren_US

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