Effect of Zinc and Melatonin Supplementation on Cellular Immunity in Rats With Toxoplasmosis
Yükleniyor...
Dosyalar
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Humana Press Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The effects of zinc (Zn) and/or melatonin supplementation on cellular immunity were investigated in rats infested with Toxoplasma gondii. Fifty Sprague-Dawley male rats were used for this study. All animals were fed a normal diet, ad libitum, containing 97 mg Zn/kg. They were divided into five experimental groups, as follows. Group I (n = 10) received intraperitoneal injections of zinc sulfate at a dose of 3 mg/kg/d for 3 wk. Group II (n = 10) received intraperitoneal injections of melatonin at a dose of 3 mg/kg/d for 3 wk. Group III (n = 10) received intraperitoneal injections of zinc sulfate (3 mg/kg/d) and melatonin (3 mg/kg/d) for 3 wk. Group IV (n = 10) was infested controls. Group V (n = 10) was healthy controls. There were no differences in the percentage of CD3+ lymphocytes among all groups. For groups I-III, the CD4+ and CD8+ ratios were higher than those of the groups IV and V controls (p < 0.01). Similarly, the total lymphocyte ratios in groups I-III were higher than those of infested and healthy controls (p < 0.01). The total lymphocyte ratios in group III were significantly higher than those of groups I and 11 (p < 0.01). The plasma Zn levels in the supplemented groups were significantly higher than those of control groups IV and V (p < 0.01). These results suggest that melatonin and/or Zn supplementation may activate cellular immunity by stimulating CD4+ and CD8+ production in infected rats with T. gondii.
Açıklama
Anahtar Kelimeler
Cellular İmmunity, Melatonin, Toxoplasmosis, Toxoplasma Gondii, Zinc Supplementation
Kaynak
Biological Trace Element Research
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
96
Sayı
Künye
Baltacı, A. K., Bediz, C. Ş., Moğulkoç, R., Kurtoğlu, E., Pekel, A., (2003). Effect of Zinc and Melatonin Supplementation on Cellular Immunity in Rats With Toxoplasmosis. Biological Trace Element Research, (96), 237-245. Doi: 10.1385/BTER:96:1-3:237
