Effect of Zinc and Melatonin Supplementation on Cellular Immunity in Rats With Toxoplasmosis

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dc.contributor.authorBaltacı, Abdülkerim Kasım
dc.contributor.authorBediz, Cem Şeref
dc.contributor.authorMoğulkoç, Rasim
dc.contributor.authorKurtoğlu, Erdal
dc.contributor.authorPekel, Aysel
dc.date.accessioned2020-03-26T16:45:38Z
dc.date.available2020-03-26T16:45:38Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe effects of zinc (Zn) and/or melatonin supplementation on cellular immunity were investigated in rats infested with Toxoplasma gondii. Fifty Sprague-Dawley male rats were used for this study. All animals were fed a normal diet, ad libitum, containing 97 mg Zn/kg. They were divided into five experimental groups, as follows. Group I (n = 10) received intraperitoneal injections of zinc sulfate at a dose of 3 mg/kg/d for 3 wk. Group II (n = 10) received intraperitoneal injections of melatonin at a dose of 3 mg/kg/d for 3 wk. Group III (n = 10) received intraperitoneal injections of zinc sulfate (3 mg/kg/d) and melatonin (3 mg/kg/d) for 3 wk. Group IV (n = 10) was infested controls. Group V (n = 10) was healthy controls. There were no differences in the percentage of CD3+ lymphocytes among all groups. For groups I-III, the CD4+ and CD8+ ratios were higher than those of the groups IV and V controls (p < 0.01). Similarly, the total lymphocyte ratios in groups I-III were higher than those of infested and healthy controls (p < 0.01). The total lymphocyte ratios in group III were significantly higher than those of groups I and 11 (p < 0.01). The plasma Zn levels in the supplemented groups were significantly higher than those of control groups IV and V (p < 0.01). These results suggest that melatonin and/or Zn supplementation may activate cellular immunity by stimulating CD4+ and CD8+ production in infected rats with T. gondii.en_US
dc.identifier.citationBaltacı, A. K., Bediz, C. Ş., Moğulkoç, R., Kurtoğlu, E., Pekel, A., (2003). Effect of Zinc and Melatonin Supplementation on Cellular Immunity in Rats With Toxoplasmosis. Biological Trace Element Research, (96), 237-245. Doi: 10.1385/BTER:96:1-3:237
dc.identifier.doi10.1385/BTER:96:1-3:237en_US
dc.identifier.endpage245en_US
dc.identifier.issn0163-4984en_US
dc.identifier.pmid14716103en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage237en_US
dc.identifier.urihttps://dx.doi.org/10.1385/BTER:96:1-3:237
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18437
dc.identifier.volume96en_US
dc.identifier.wosWOS:000187916600022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBaltacı, Abdülkerim Kasım
dc.institutionauthorBediz, Cem Şeref
dc.institutionauthorKurtoğlu, Erdal
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCellular İmmunityen_US
dc.subjectMelatoninen_US
dc.subjectToxoplasmosisen_US
dc.subjectToxoplasma Gondiien_US
dc.subjectZinc Supplementationen_US
dc.titleEffect of Zinc and Melatonin Supplementation on Cellular Immunity in Rats With Toxoplasmosisen_US
dc.typeArticleen_US

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