Molecular Mechanisms of Early and Late LTP
Yükleniyor...
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
SPRINGER/PLENUM PUBLISHERS
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
LTP is the most intensively studied cellular model of the memory and generally divided at least two distinct phases as early and late. E-LTP requires activation of CaMKII that initiates biochemical events and trafficking of proteins, which eventually potentiate synaptic transmission, and is independent of de novo protein synthesis. In contrast, L-LTP requires gene expression and local protein synthesis regulated via TrkB receptor- and functional prions CPEB2-3-mediated translation. Maintenance of LTP for longer periods depends on constitutively active PKM. Throughout this review, current knowledge about early and late phases of LTP will be reviewed.
Açıklama
Anahtar Kelimeler
Ltp, Functional prions, Cpeb, Pkm zeta, Synaptic plasticity, Learning and memory
Kaynak
NEUROCHEMICAL RESEARCH
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
44
Sayı
2
Künye
Baltaci, S. B., Mogulkoc, R., Baltaci, A. K. (2019). Molecular Mechanisms Of Early And Late LTP. Neurochemical Research, 44,(2), 281-296.
