Molecular Mechanisms of Early and Late LTP

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dc.contributor.authorBaltaci, Saltuk Bugra
dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.date.accessioned2020-03-26T20:15:16Z
dc.date.available2020-03-26T20:15:16Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractLTP is the most intensively studied cellular model of the memory and generally divided at least two distinct phases as early and late. E-LTP requires activation of CaMKII that initiates biochemical events and trafficking of proteins, which eventually potentiate synaptic transmission, and is independent of de novo protein synthesis. In contrast, L-LTP requires gene expression and local protein synthesis regulated via TrkB receptor- and functional prions CPEB2-3-mediated translation. Maintenance of LTP for longer periods depends on constitutively active PKM. Throughout this review, current knowledge about early and late phases of LTP will be reviewed.en_US
dc.identifier.citationBaltaci, S. B., Mogulkoc, R., Baltaci, A. K. (2019). Molecular Mechanisms Of Early And Late LTP. Neurochemical Research, 44,(2), 281-296.
dc.identifier.doi10.1007/s11064-018-2695-4en_US
dc.identifier.endpage296en_US
dc.identifier.issn0364-3190en_US
dc.identifier.issn1573-6903en_US
dc.identifier.issue2en_US
dc.identifier.pmid30523578en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage281en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11064-018-2695-4
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38008
dc.identifier.volume44en_US
dc.identifier.wosWOS:000458993300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBaltaci, Saltuk Bugra
dc.institutionauthorMogulkoc, Rasim
dc.institutionauthorBaltaci, Abdulkerim Kasim
dc.language.isoenen_US
dc.publisherSPRINGER/PLENUM PUBLISHERSen_US
dc.relation.ispartofNEUROCHEMICAL RESEARCHen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectLtpen_US
dc.subjectFunctional prionsen_US
dc.subjectCpeben_US
dc.subjectPkm zetaen_US
dc.subjectSynaptic plasticityen_US
dc.subjectLearning and memoryen_US
dc.titleMolecular Mechanisms of Early and Late LTPen_US
dc.typeReviewen_US

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