Response to Vasoconstrictor Agents by Detrusor Smooth Muscles From Cisplatin-Treated Rats and Antioxidant Treatment

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dc.contributor.authorAtalık, Kısmet Esra
dc.contributor.authorKeleş, Bahar
dc.contributor.authorUyar, Yavuz
dc.contributor.authorDündar, M. A.
dc.contributor.authorÖz, M.
dc.contributor.authorEsen, H. H.
dc.date.accessioned2020-03-26T18:04:56Z
dc.date.available2020-03-26T18:04:56Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe effects of melatonin and quercetin on the contractile responses of cisplatin-treated rat detrusor smooth muscle were tested. Detrusor strips obtained from four separate rat groups (control, cisplatin, melatonin+cisplatin and quercetin+cisplatin) were mounted in 25 mL organ baths containing Krebs-Henseleit solution (KHS) at 37 degrees C, continuously gassed with 95% O(2) and 5% CO(2). The vasoconstriction induced by acetylcholine (ACh) and potassium chloride (KCl) were compared within the groups. Furthermore, histopathological parameters such as edema, congestion, inflammatory cells, microvascular proliferation, fibrosis, eosinophil, most cells and epithelial damage were noted. In routine experiments ACh and KCl triggered concentration-dependent contractions. Pretreatment with cisplatin increased the sensitivity but not the maximal response to ACh and KCl. In rats treated with melatonin or quercetin before cisplatin, the EC(50) values, but not the maximal response, to both agents were significantly higher than in the cisplatin-treated (CII) group. Histopathological parameters such as edema, congestion, inflammatory cells, microvascular proliferation, fibrosis, eosinophil, most cells and epithelial damage were all higher in the cisplatin-treated group than in the controls. Melatonin pretreatment significantly decreased mast cell numbers and epithelial damage when compared to cisplatin treatment alone but these effects were not recorded with quercetin pretreatment. These results demonstrate for the first time that melatonin can attenuate urinary bladder injury produced by cisplatin treatment.en_US
dc.description.sponsorshipScientific Research Foundation of Selcuk UniversitySelcuk Universityen_US
dc.description.sponsorshipThis study is supported by the Scientific Research Foundation of Selcuk University.en_US
dc.identifier.citationAtalık, K. E., Keleş, B., Uyar, Y., Dündar, M. A., Öz, M., Esen, H. H., (2010). Response to Vasoconstrictor Agents by Detrusor Smooth Muscles From Cisplatin-Treated Rats and Antioxidant Treatment. Methods and Findings in Experimental and Clinical Pharmacology, 32(5), 305-310. Doi: 10.1358/mf.2010.32.5.1423893
dc.identifier.doi10.1358/mf.2010.32.5.1423893en_US
dc.identifier.endpage310en_US
dc.identifier.issn0379-0355en_US
dc.identifier.issue5en_US
dc.identifier.pmid20664820en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage305en_US
dc.identifier.urihttps://dx.doi.org/10.1358/mf.2010.32.5.1423893
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25233
dc.identifier.volume32en_US
dc.identifier.wosWOS:000281835100003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAtalık, Kısmet Esra
dc.institutionauthorKeleş, Bahar
dc.institutionauthorDündar, M. A.
dc.institutionauthorÖz, M.
dc.institutionauthorEsen, H. H.
dc.language.isoenen_US
dc.publisherProus Science, Sa-thomson Reutersen_US
dc.relation.ispartofMethods and Findings in Experimental and Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleResponse to Vasoconstrictor Agents by Detrusor Smooth Muscles From Cisplatin-Treated Rats and Antioxidant Treatmenten_US
dc.typeArticleen_US

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