Zinc Deficiency and Supplementation in Ovariectomized Rats: Their Effect on Serum Estrogen and Progesterone Levels and Their Relation to Calcium and Phosphorus

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dc.contributor.authorSunar, Füsun
dc.contributor.authorBaltacı, Abdulkerim Kasım
dc.contributor.authorErgene, Neyhan
dc.contributor.authorMoğulkoç, Rasim
dc.date.accessioned2020-03-26T17:41:14Z
dc.date.available2020-03-26T17:41:14Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study is to examine how zinc deficiency or supplementation affects estrogen and progesterone and calcium and phosphorus levels in the serum. The study was carried out on 40 adult female rats of Spraque-Dawley species. The rats were allocated to four groups: Group 1: Control, Group 2: Ovariectomized (OVX) control. Group 3: OVX-Zinc-supplemented. Group 4: OVX-Zinc-deficient. Blood samples were taken from the experimental animals by decapitation method and analyzed in terms of estrogen, progesterone, calcium, phosphorus, magnesium and zinc levels. Group 1 had the highest estrogen levels (p<0.05). Estrogen levels in group 3 were higher than those in groups 2 and 4 (p<0.05). The lowest estrogen levels were found in group 4 (p<0.05). Progesterone levels were higher in group I than in groups 2, 3 and 4 and the same parameter in group 3 was higher than those in groups 2 and 4. The highest calcium and phosphorus levels were obtained in groups I and 3 (p<0.05). Calcium and phosphorus levels in group 2 were higher than those in group 4 (p<0.05). There was no difference among groups with regard to magnesium levels. Group 3 had the highest serum zinc levels (p<0.05). Zinc levels in group I were higher than those in groups 2 and 4 and the levels in group 2 were higher than those in group 4. Findings of the study show that zinc deficiency causes a significant decrease in calcium and phosphorus levels and that zinc supplementation prevents these adversities in ovariectomized rats.en_US
dc.identifier.citationSunar, F., Baltacı, A. K., Ergene, N., Moğulkoç, R., (2009). Zinc Deficiency and Supplementation in Ovariectomized Rats: Their Effect on Serum Estrogen and Progesterone Levels and Their Relation to Calcium and Phosphorus. Pakistan Journal of Pharmaceutical Sciences, 22(2), 150-154.
dc.identifier.endpage154en_US
dc.identifier.issn1011-601Xen_US
dc.identifier.issue2en_US
dc.identifier.pmid19339224en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage150en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24028
dc.identifier.volume22en_US
dc.identifier.wosWOS:000270501000006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSunar, Füsun
dc.institutionauthorBaltacı, Abdulkerim Kasım
dc.institutionauthorErgene, Neyhan
dc.institutionauthorMoğulkoç, Rasim
dc.language.isoenen_US
dc.publisherUniv Karachien_US
dc.relation.ispartofPakistan Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectOvariectomyen_US
dc.subjectzincen_US
dc.subjectovary hormonesen_US
dc.subjectcalcium and phosphorusen_US
dc.titleZinc Deficiency and Supplementation in Ovariectomized Rats: Their Effect on Serum Estrogen and Progesterone Levels and Their Relation to Calcium and Phosphorusen_US
dc.typeArticleen_US

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