Comparison of the Effects of Intravenous Administration of Isotonic and Hypertonic Sodium Bicarbonate Solutions on Venous Acid-Base Status in Dehydrated Calves with Strong Ion Acidosis
Yükleniyor...
Dosyalar
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
AMER VETERINARY MEDICAL ASSOC
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective-To compare the effects of IV administration of isotonic (1.3%) and hypertonic (8.4%) sodium bicarbonate (NaHCO3) solutions on acid-base status in dehydrated calves with strong ion (metabolic) acidosis. Design-Randomized controlled clinical trial. Animals-50 calves with diarrhea and severe dehydration. Procedures-Calves were randomly assigned to receive isotonic NaHCO3 solution (65 mL/kg [29.5 mL/Ib], IV) over 3 hours (n = 30) or hypertonic NaHCO3 solution (10 mL/kg [4.5 mL/Ib], IV) over 20 minutes (20). Blood samples were collected at 0 hours (immediately prior to solution administration) and at 0.5, 1, 2, and 4 hours after administration began. Samples were submitted for blood gas analysis, serum biochemical analysis, and determination of blood Na+, K+, and Cl- concentrations and percentage change in plasma volume. Results Calves that received isotonic NaHCO3 solution had an increase in venous blood pH, HCO3 concentration, and base excess; a small, transient increase in PO2; and no change in PCO2 within 4 hours after administration began. Calves that received hypertonic NaHCO3 solution had an immediate increase in venous blood pH, HCO3 concentration, and base excess; a small, transient increase PCO2; and no change in PO2 within 0.5 hours after treatment began. Plasma volume increased to a greater extent following administration of isotonic solution than after administration of hypertonic solution. Conclusions and Clinical Relevance-IV administration of 8.4% NaHCO3 solution in small volumes provided fast and effective improvement of severe acid-base abnormalities in calves with severe strong ion acidosis but did not improve hydration status as well as administration of a larger volume of isotonic NaHCO3 solution.
Açıklama
Anahtar Kelimeler
Kaynak
Javma-Journal of the American Veterinary Medical Association
WoS Q Değeri
Q1
Scopus Q Değeri
Q2
Cilt
236
Sayı
10
Künye
Şen, İ., Coşkun, A., Güzelbekteş, H., Ok, M., Turgut, K., Canikli, Ş., (2010). Comparison of the Effects of Intravenous Administration of Isotonic and Hypertonic Sodium Bicarbonate Solutions on Venous Acid-Base Status in Dehydrated Calves with Strong Ion Acidosis. Javma-Journal of the American Veterinary Medical Association, 236(10), 1098-1103. Doi:10.2460/javma.236.10.1098
