Comparison of the Effects of Intravenous Administration of Isotonic and Hypertonic Sodium Bicarbonate Solutions on Venous Acid-Base Status in Dehydrated Calves with Strong Ion Acidosis

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dc.contributor.authorCoşkun, Alparslan
dc.contributor.authorŞen, İsmail
dc.contributor.authorGüzelbekteş, Hasan
dc.contributor.authorOk, Mahmut
dc.contributor.authorTurgut, Kürşat
dc.contributor.authorCanikli, Şebnem
dc.date.accessioned2020-03-26T17:47:36Z
dc.date.available2020-03-26T17:47:36Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective-To compare the effects of IV administration of isotonic (1.3%) and hypertonic (8.4%) sodium bicarbonate (NaHCO3) solutions on acid-base status in dehydrated calves with strong ion (metabolic) acidosis. Design-Randomized controlled clinical trial. Animals-50 calves with diarrhea and severe dehydration. Procedures-Calves were randomly assigned to receive isotonic NaHCO3 solution (65 mL/kg [29.5 mL/Ib], IV) over 3 hours (n = 30) or hypertonic NaHCO3 solution (10 mL/kg [4.5 mL/Ib], IV) over 20 minutes (20). Blood samples were collected at 0 hours (immediately prior to solution administration) and at 0.5, 1, 2, and 4 hours after administration began. Samples were submitted for blood gas analysis, serum biochemical analysis, and determination of blood Na+, K+, and Cl- concentrations and percentage change in plasma volume. Results Calves that received isotonic NaHCO3 solution had an increase in venous blood pH, HCO3 concentration, and base excess; a small, transient increase in PO2; and no change in PCO2 within 4 hours after administration began. Calves that received hypertonic NaHCO3 solution had an immediate increase in venous blood pH, HCO3 concentration, and base excess; a small, transient increase PCO2; and no change in PO2 within 0.5 hours after treatment began. Plasma volume increased to a greater extent following administration of isotonic solution than after administration of hypertonic solution. Conclusions and Clinical Relevance-IV administration of 8.4% NaHCO3 solution in small volumes provided fast and effective improvement of severe acid-base abnormalities in calves with severe strong ion acidosis but did not improve hydration status as well as administration of a larger volume of isotonic NaHCO3 solution.en_US
dc.description.sponsorshipSU Scientific Research OfficeSelcuk Universityen_US
dc.description.sponsorshipSupported by a grant from SU Scientific Research Office.en_US
dc.identifier.citationŞen, İ., Coşkun, A., Güzelbekteş, H., Ok, M., Turgut, K., Canikli, Ş., (2010). Comparison of the Effects of Intravenous Administration of Isotonic and Hypertonic Sodium Bicarbonate Solutions on Venous Acid-Base Status in Dehydrated Calves with Strong Ion Acidosis. Javma-Journal of the American Veterinary Medical Association, 236(10), 1098-1103. Doi:10.2460/javma.236.10.1098
dc.identifier.doi10.2460/javma.236.10.1098en_US
dc.identifier.endpage1103en_US
dc.identifier.issn0003-1488en_US
dc.identifier.issn1943-569Xen_US
dc.identifier.issue10en_US
dc.identifier.pmid20470072en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1098en_US
dc.identifier.urihttps://dx.doi.org/10.2460/javma.236.10.1098
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24730
dc.identifier.volume236en_US
dc.identifier.wosWOS:000277661700025en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAMER VETERINARY MEDICAL ASSOCen_US
dc.relation.ispartofJavma-Journal of the American Veterinary Medical Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleComparison of the Effects of Intravenous Administration of Isotonic and Hypertonic Sodium Bicarbonate Solutions on Venous Acid-Base Status in Dehydrated Calves with Strong Ion Acidosisen_US
dc.typeArticleen_US

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