Evaluation of Leptin Level and Ob Gene Polymorphism in Patients With Behcet's Disease
Yükleniyor...
Dosyalar
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The present study was aimed to evaluate serum leptin level and the frequency of oligopolymorphic codon 25 (CAA/CAG) of Ob gene in Behcet's disease. Eighty-seven patients with Behcet's disease and 85 healthy controls with matched age, gender and body mass index were included in the study. Serum leptin level was determined and genotype of codon 25 of Ob gene was performed by using the PCR amplification after DNA extraction. Serum leptin concentration of the patients with Behcet's disease (23.8 +/- 22.8 ng/ml) was higher than that of the control groups (17.1 +/- 14.7 ng/ml). The patients with Behcet's disease and control subjects showed CAA/CAA genotype, indicating the presence of no polymorphism. Neither Behcet's disease nor serum leptin level was found to be related to codon 25 polymorphism. We concluded that leptin 25CAG polymorphism is not associated with Behcet's disease and serum leptin level.
Açıklama
Anahtar Kelimeler
Behcet's disease, leptin, Ob gene, polymorphism
Kaynak
Archives of Dermatological Research
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
298
Sayı
Künye
Okudan, N., Acar, H., Gökbel, H., Mevlitoğlu, İ., Sarı, F., (2006). Evaluation of Leptin Level and Ob Gene Polymorphism in Patients With Behcet's Disease. Archives of Dermatological Research, (298), 127-130. Doi: 10.1007/s00403-006-0669-x
