Intravenous pharmacokinetics of moxifloxacin following simultaneous administration with flunixin meglumine or diclofenac in sheep

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dc.contributor.authorAltan, Feray
dc.contributor.authorCorum, Orhan
dc.contributor.authorYildiz, Ramazan
dc.contributor.authorFaki, Hatice Eser
dc.contributor.authorIder, Merve
dc.contributor.authorOk, Mahmut
dc.contributor.authorUney, Kamil
dc.date.accessioned2020-03-26T20:14:49Z
dc.date.available2020-03-26T20:14:49Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümüen_US
dc.description.abstractIn this study, the pharmacokinetics of moxifloxacin (5 mg/kg) was determined following a single intravenous administration of moxifloxacin alone and co-administration with diclofenac (2.5 mg/kg) or flunixin meglumine (2.2 mg/kg) in sheep. Six healthy Akkaraman sheep (2 +/- 0.3 years and 53.5 +/- 5 kg of body weight) were used. A longitudinal design with a 15-day washout period was used in three periods. In the first period, moxifloxacin was administered by an intravenous (IV) injection. In the second and third periods, moxifloxacin was co-administered with IV administration of diclofenac and flunixin meglumine, respectively. The plasma concentration of moxifloxacin was assayed by high-performance liquid chromatography. The pharmacokinetic parameters were calculated using a two-compartment open pharmacokinetic model. Following IV administration of moxifloxacin alone, the mean elimination half-life (t(1/2 beta)), total body clearance (Cl-T), volume of distribution at steady state (V-dss) and area under the curve (AUC) of moxifloxacin were 2.27 hr, 0.56 L h(-1) kg(-1), 1.66 L/kg and 8.91 hr*mu g/ml, respectively. While diclofenac and flunixin meglumine significantly increased the t(1/2 beta) and AUC of moxifloxacin, they significantly reduced the Cl-T and V-dss. These results suggest that anti-inflammatory drugs could increase the therapeutic efficacy of moxifloxacin by altering its pharmacokinetics.en_US
dc.description.sponsorshipCoordination of Scientific Research Projects, University of Selcuk, Turkey [17401058]en_US
dc.description.sponsorshipThe Coordination of Scientific Research Projects, University of Selcuk, Turkey, Grant/Award Number: 17401058en_US
dc.identifier.citationAltan, F., Corum, O., Yildiz, R., Eser Faki, H., Ider, M., Ok, M., Uney, K. (2020). Intravenous Pharmacokinetics Of Moxifloxacin Following Simultaneous Administration With Flunixin Meglumine Or Diclofenac İn Sheep. Journal Of Veterinary Pharmacology And Therapeutics, 43,(2), 108-114.
dc.identifier.doi10.1111/jvp.12841en_US
dc.identifier.issn0140-7783en_US
dc.identifier.issn1365-2885en_US
dc.identifier.pmid32043623en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1111/jvp.12841
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37939
dc.identifier.wosWOS:000512441400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorFaki, Hatice Eser
dc.institutionauthorIder, Merve
dc.institutionauthorOk, Mahmut
dc.institutionauthorUney, Kamil
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectdiclofenacen_US
dc.subjectflunixin meglumineen_US
dc.subjectmoxifloxacinen_US
dc.subjectpharmacokineticsen_US
dc.subjectsheepen_US
dc.titleIntravenous pharmacokinetics of moxifloxacin following simultaneous administration with flunixin meglumine or diclofenac in sheepen_US
dc.typeArticleen_US

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