Autologous Transplantation of Arterial Cells Improves Cardiac Function in a Rabbit Model of Infarcted Myocardium

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dc.contributor.authorTokaç, Mehmet
dc.contributor.authorAktan, Murad
dc.contributor.authorAk, Ahmet
dc.contributor.authorDuman, Selçuk
dc.contributor.authorTokgözoğlu, Lale
dc.contributor.authorAygül, Nazif
dc.contributor.authorPaksoy, Yahya
dc.contributor.authorPorat, Yael
dc.date.accessioned2020-03-26T17:47:10Z
dc.date.available2020-03-26T17:47:10Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractCellular cardiomyoplasty is a promising approach for the treatment of severe heart failure. However, the question which cell line is the best to use is still a matter of debate. In this study, we aimed to evaluate the efficacy of arterial media-intima cell suspension (AMICS) transplantation in rabbit myocardial infarct model. The study was divided into 2 groups: group A (the cell-treated group, n = 9) and group B (the medium injection group, n = 8). Group A was further divided into 2 subgroups as branch-1 (treated with unlabeled cells) and branch-2 (treated with iron-labeled cells). The experimental myocardial infarction (MI) was induced by ligation of left anterior descending coronary artery with a combination of cryoinjury. Ten days after the MI, cells obtained from autologous femoral arteries were injected into the injured myocardium of group A, while group B received an injection of only DMEM medium. Clinical, echocardiographic, and histopathologic evaluations were done. As compared to the ninth day values, echocardiography showed a significant improvement in systolic functions and left ventricular (LV) dimensions of the cell-treated group on the 30th day. In the heart biopsy sections of branch-1, the immunostained injected cells were observed to exist closely, suggesting an organization. Cells existing separately and lumen-like structure organizations stained positive with both smooth muscle cell (SMC) a-actin and Prussian Blue were also showed in the histological observation of branch-2. Autologous AMICS transplantation seems to be a feasible and efficacious method for cellular cardiomyoplasty in our rabbit model.en_US
dc.identifier.citationTokaç, M., Aktan, M., Ak, A., Duman, S., Tokgözoğlu, L., Aygül, N., Paksoy, Y., Porat, Y., (2010). Autologous Transplantation of Arterial Cells Improves Cardiac Function in a Rabbit Model of Infarcted Myocardium. Stem Cells and Development, 19(6), 927-934. Doi: 10.1089/scd.2009.0140
dc.identifier.doi10.1089/scd.2009.0140en_US
dc.identifier.endpage934en_US
dc.identifier.issn1547-3287en_US
dc.identifier.issn1557-8534en_US
dc.identifier.issue6en_US
dc.identifier.pmid19739969en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage927en_US
dc.identifier.urihttps://dx.doi.org/10.1089/scd.2009.0140
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24640
dc.identifier.volume19en_US
dc.identifier.wosWOS:000279033900016en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTokaç, Mehmet
dc.institutionauthorAktan, Murad
dc.institutionauthorAk, Ahmet
dc.institutionauthorPaksoy, Yahya
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofStem Cells and Developmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleAutologous Transplantation of Arterial Cells Improves Cardiac Function in a Rabbit Model of Infarcted Myocardiumen_US
dc.typeArticleen_US

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