Species-Specificity of Growth-Promoting Effects of Prolactin During Rat Embryogenesis

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dc.contributor.authorKarabulut, A. K.
dc.contributor.authorPratten, M. K.
dc.date.accessioned2020-03-26T16:26:19Z
dc.date.available2020-03-26T16:26:19Z
dc.date.issued1998
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn the early stages of embryonic development, many growth-promoting molecules must be provided by the maternal system. The molecules involved in growth processes may be either hormones or growth factors, or molecules that interact with such factors. The pregnancy related hormone, prolactin (PRL, MW 23 kDa) has been implicated in the control of embryonic growth. The growth-promoting potential of PRL and its species-specificity was investigated by culturing 9.5 d rat embryos in vitro for 48 h in depleted serum in the presence and absence of PRL from 3 different species. The growth-supporting capacity of the serum was reduced by removal of low molecular weight molecules by prolonged filtration of the serum using filters with a molecular weight exclusion of 30 kDa. This method provided a 'semidefined' medium (retenate) in which embryonic growth and development was significantly reduced, demonstrating that the low molecular weight fraction of serum may contain some growth-promoting factors. Addition of PRL (0.4-25.6 ng/ml) from different species (human, sheep and rat) to retenate significantly improved embryonic growth and development, suggesting that the developing embryo may utilise PRL. Amongst PRLs, rat PRL was found to be active at much lower concentrations than either of the other molecules, and human PRL had more effect in low concentrations than sheep PRL suggesting a species-specificity for this hormone. It may be that the PRL receptors of the rat embryos have greater affinity for the rat hormone as different responses for hormones from different species have been shown. These findings suggest that embryos may be able to utilise maternally derived PRL during organogenesis.en_US
dc.identifier.citationKarabulut, A. K., Pratten, M. K., (1998). Species-Specificity of Growth-Promoting Effects of Prolactin During Rat Embryogenesis. Journal of Anatomy, 192(1998), 1-12. Doi:10.1046/j.1469-7580.1998.19210001.x
dc.identifier.doi10.1046/j.1469-7580.1998.19210001.xen_US
dc.identifier.endpage12en_US
dc.identifier.issn0021-8782en_US
dc.identifier.issn1469-7580en_US
dc.identifier.pmid9568556en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://dx.doi.org/10.1046/j.1469-7580.1998.19210001.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16795
dc.identifier.volume192en_US
dc.identifier.wosWOS:000072900100001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKarabulut, A. K.
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJournal of Anatomyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectWhole Embryo Cultureen_US
dc.subjectRaten_US
dc.subjectOrganogenesisen_US
dc.subjectDevelopmenten_US
dc.titleSpecies-Specificity of Growth-Promoting Effects of Prolactin During Rat Embryogenesisen_US
dc.typeArticleen_US

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