Effect of Melatonin on Epididymal Sperm Quality After Testicular Ischemia/Reperfusion in Rats

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dc.contributor.authorKurçer, Zehra
dc.contributor.authorHekimoğlu, Aşkın
dc.contributor.authorAral, Faruk
dc.contributor.authorBaba, Füsun
dc.contributor.authorSahna, Engin
dc.date.accessioned2020-03-26T17:48:00Z
dc.date.available2020-03-26T17:48:00Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To determine the effect of melatonin, a pineal secretory product that prevents testicular ischemia/reperfusion (IR) injury through its antioxidative properties, on epididymal sperm quality in a rat testicular IR injury model. Design: Experimental study. Setting: University pharmacology laboratory. Animal(s): Fifty-six 8-week-old male Wistar albino rats. Intervention(s): Left testicular artery and vein occluded for I hour; before the bilateral orchiectomy, the organ was allowed to reperfuse 30 days. Melatonin (10 mg/kg IP) or vehicle (1% ethanol in saline) was administrated for 10 minutes before reperfusion and for 1 hour after reperfusion. Main Outcome Measure(s): After 24 hours of reperfusion, the rats were decapitated, and the testicular tissue samples were obtained for histologic examination. In addition, after 30 days of reperfusion, the epididymal sperm concentration, motility, and abnormal sperm rates were determined in the sperm collected from the epididymis. Result(s): A statistically significant decrease in sperm concentration resulted from IR as well as an increase in sperm abnormalities, but the sperm motility did not change. Melatonin treatment did not prevent the IR-induced reduction in sperm concentration. However, melatonin treatment statistically significantly decreased the sperm abnormalities when compared with the IR injured samples. Conclusion(s): Melatonin may improve sperm morphology for a protective effect in IR-induced testicular injury.en_US
dc.identifier.citationBaba, F., Kurçer, Z., Hekimoğlu, A., Aral, F., Sahna, E., (2010). Effect of Melatonin on Epididymal Sperm Quality After Testicular Ischemia/Reperfusion in Rats. Fertility and Sterility, 93(5), 1545-1549. Doi:10.1016/j.fertnstert.2009.01.146
dc.identifier.doi10.1016/j.fertnstert.2009.01.146en_US
dc.identifier.endpage1549en_US
dc.identifier.issn0015-0282en_US
dc.identifier.issue5en_US
dc.identifier.pmid19328481en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1545en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.fertnstert.2009.01.146
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24808
dc.identifier.volume93en_US
dc.identifier.wosWOS:000276038700022en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBaba, Füsun
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofFERTILITY AND STERILITYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectmelatoninen_US
dc.subjecttesticular ischemia/reperfusionen_US
dc.subjectsperm concentrationen_US
dc.subjectsperm motilityen_US
dc.subjectsperm morphologyen_US
dc.titleEffect of Melatonin on Epididymal Sperm Quality After Testicular Ischemia/Reperfusion in Ratsen_US
dc.typeArticleen_US

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